Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-07-27
2000-07-18
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
426 121, 426 9321, 426 951, 436 73, 436501, 436504, 436518, 431523, 431829, A61K 9127
Patent
active
060904089
ABSTRACT:
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
REFERENCES:
patent: 5290960 (1994-03-01), Singh
patent: 5527528 (1996-06-01), Allen
patent: 5534241 (1996-07-01), Torchilin
Spevak, W., "The Presentation of Biological Ligands on the Surface of Polymerized Monolayers and Liposomes" (1988) Ph.D. dissertation in Chemistry Dept. at University of California at Berkeley. (see especially Chapter 4, pp. 110-133).
Dialog.RTM. Abstract of Spevak, W.R., "The Presentation of Biological Ligands on the Surface of Polymerized Monolayers and Liposomes" Dissertatin submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemistry, University of California at Berkeley, 1994. One page total.
Charych et al., "Artificial cell membranes for diagnostics and therapeutics" Chem Tech (Sep. 1996) pp. 24-28.
Charych et al., "Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly" Science (1993) 261:585-589.
Hub et al., "Polymerizable phospholipid analogues--New stable biomembrane and cell models" Angew. Chem. Int. Ed. Engl. (1980) 19(11):938-940.
Lin et al., "Liposome-like Fucopeptides as Sialyl Lewis X Mimetics" Bioorg. Med. Chem. Ltrs. (1996) 6(22):2755-2760.
Nagy et al., "Polymerized liposomes containing C-glycosides of sialic acid are potent inhibitors of influenza virus hemagglutination and in vitro infectivity" J. Cell. Biochem. (1993) Supplement 17A p. 382, Abstract CA 403. (Abstract only).
Reichert et al., "Polydiacetylene liposomes functionalized with sialic acid bind and colorimetrically detect influenza virus" J. Am. Chem. Soc. (1995) 117:829-830.
Sipkins et al., "Antibody-conjugated paramagnetic liposomes (ACPLs): Tissure specific contrast agents for disease processes" Radiology (1995) 197:276 (Abstract only).
Sipkins et al., "MR Imaging of tumor-induced angiogenesis using antibody-conjugated pramagnetic liposomes" Radiology (1995) 197:129 (Abstract only).
Spevak et al., "An Efficient synthesis of N-Allyglycosylamides from unprotected carbohydrates" J. Org. Chem. (1996) 61:3417-3422.
Spevak et al., "Carbohydrates in an acidic multivalent assembly: Nanomolar P-selectin inhibitors" J. Med. Chem. (1996) 39:1018-1020.
Spevak et al., "Molecular assemblies of functionalized polydiacetylenes" Adv. Mater. (1995) 7(1):85-89.
Spevak et al., "Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity" J. Am. Chem. Soc. (1993) 115:1146-1147.
Storrs et al., "Paramagnetic Polymerized Liposomes as New Recirculating MR Contrast Agents" JMRI (1995) 5(6):719-724.
Bednarski Mark David
Kuniyoshi Jeremy Kenji
Li Henry Y.
Li King Chuen
Sipkins Dorothy Anna
Kishore Gollamudi S.
Targesome, Inc.
LandOfFree
Use of polymerized lipid diagnostic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of polymerized lipid diagnostic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of polymerized lipid diagnostic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2033942