Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-06-09
1995-07-11
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514674, 564197, 564512, A61K 3116, A61K 3113
Patent
active
054322022
ABSTRACT:
Methods for regulating cation transport across cellular membranes possessing cation channels are provided. The cell membrane possessing a specific ion channel is exposed to a non-aromatic polyamine compound having a lysine- or arginine-based moiety (or a guanidine moiety) coupled to a straight chain polyamine.
These polyamines as well as a method for regulating NMDA through a spermidine-like effect on NMDA receptors by exposing a cell membrane to selected polyamines are also provided.
REFERENCES:
patent: 3574747 (1971-04-01), Denning et al.
patent: 4259259 (1981-03-01), McEntire
patent: 4507321 (1985-03-01), Raisfeld
Meadows et al., Toxicon, 8:311-312, 1970.
Gregson, R. P., et al., Comp. Biochem. Physiol., 74C (1):125-132, 1983.
Scheumack, D. D., et al., Febs. Letters, 191 (1):154-156, 1985.
Jackson, H., et al., Soc. Neurosci. Abstr. 185 p. 107, 32.17, 1985.
Curtis, B. M., et al., Biochem. 25:3077-3083, 1986.
Adams, M. E., et al., Insect Neurophysiol. Pap. Int. Conf. Second, pp. 397-400, 1986.
Jackson, H., et al., In Excitatory Amino Acid Transmission, (Alan R. Lis, Inc.), pp. 51-54, 1987.
Miller, R. J., Science, 235:46,52 1987.
Bowers, C. W., et al., PNAS (USA), 84:3506-3510, 1987.
Sugimori, M., et al., Soc. Neurosci Abstr., 13 p. 228, 69.1, 1987.
Kerr, L. M., et al., Soc. Neurosci. Abstr., 13 p. 102, 31.15, 1987.
Lai, F. A., et al, Nature, 331:315-319, 1988.
Spence, J, Neurotoxins, Fundam. Clin. Adv. (Int's Conf.), pp. 161-173, 1979.
Jackson, H., et al., TINS, 11:278-283, 1988.
Palade, "Drug Induced Ca.sup.2+ Release from Isolated Sarcoplasmic Reticulum", The Journal of Biological Chemistry, 262, 1, 33, 37:13 pp. 6149-6154, May 5, 1987.
Llinas et al., "Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison", Proc. Natl. Sci., 86:1689-1693, Mar., 1989.
Llinas et al, "Voltage-dependent Calcium Conductances in Mammalian Neurons, The P Channel", Annuals New York Academy of Sciences, 560:103-111, 1989.
M. Niitsu, et al., "Synthesis of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals", Chem. Pharm. Bull., 34, 3:1032-1038, 1986.
M. Israel et al., "Synthesis of Aminoethyl Derivatives of Alpha-omega-alkylenediamines and Structure-activity Relationships for the Polyamine-bovine Plasma Amine Oxidase System", Journal of Medical Chemistry, 14 (11):1042-1047, (1971).
Cherksey Bruce D.
Llinas Rodolfo R.
Sugimori Mutsuyuki
Hollrah Glennon H.
Lambkin Deborah
New York University
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