Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-07-06
1998-01-20
Shaver, Paul F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514913, A01N 4340, A61K 31445
Patent
active
057101655
ABSTRACT:
Polyamine antagonists are found to be effective in preventing or reducing visual field loss associated with glaucoma. Especially preferred are certain 1-phenyl-2-piperidinoalkanol derivatives, such as eliprodil and ifenprodil.
REFERENCES:
patent: 4690931 (1987-09-01), Wick et al.
patent: 5382576 (1995-01-01), Schoenwald et al.
patent: 5397797 (1995-03-01), Ueno
patent: 5405846 (1995-04-01), Ueno
Tung et al., "A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick," Visual Neurosci., 4:217-223 (1990).
Sisk et al., "Histological changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate," Graefe's Arch. Clin. Exp. Ophthalmol., 223:250-258 (1985).
Siliprandi et al., "N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina," Visual Neurosci., 8:567-573 (1992).
Reif-Lehrer et al., "Effects of monosodium glutamate on chick embryo retina in culture," Invest. Ophthalmol. Vis. Sci., 14(2):114-124 (1975).
Blank, J.C., "Effects of monosodium glutamate on the isolated retina of the chick embryo as a function of age: A morphological study," Exp. Eye Res., 32:105-124 (1981).
Olney et al., "The role of specific ions in glutamate neurotoxicity," Neurosci. Lett., 65:65-71 (1986).
Olney et al., "The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics," Neurosci. Lett., 68:29-34 (1986).
Price et al., "CNQX potently and selectively blocks kainate excitotoxicity in the chick embryo retina," Soc. Neurosci. Abst., 14:418 (1988).
David et al., "Involvement of excitatory neurotransmitters in the damage produced in chick embryo retinas by anoxia and extracellular high potassium," Exp. Eye Res., 46:657-662 (1988).
Caprioli et al., "Large retinal ganglion cells are more susceptible to excitotoxic and hypoxic injury than small cells," Invest. Ophthalmol. Vis. Sci., 34(Suppl.): 1429 (1993).
Cummins et al., "Electrophysiology of cultured retinal ganglion cells to investigate basic mechanics of damage," Glaucoma Update IV, 59-65 (1991).
Sucher et al., "N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro," J. Neurosci, 11(4):966-971 (1991).
Massey, S., "Cell types using glutamate as neurotransmitter in the vertebrate retina," N.N. Osborne and G.J. Chader (Eds.) Progress in Retinal Research, Ch. 9, Pergammon Press:Oxford, 339-425 (1990).
Miller et al., "Excitatory amino acid receptors in the vertebrate retina," Retinal Transmitters and Modulators: Models for the Brain, (W.W. Morgan, Ed.) CRC Press, Inc., Boca Raton, II:123-160 (1985).
Zeevalk et al., "Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainatemediated excitotoxicity," Brain Res., 522:135-139 (1990).
Ornstein et al., "Antagonists of the NMDA receptor complx," DN&P, 7(1):5-12 (1994).
Lipton, S.A., "Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide," TINS, 16(12):527-532 (1993).
Beal, M.F., "Mechanisms of excitotoxicity in neurologic diseases," FASEB J., 6:3338-3344 (1992).
Choi, D.W., "Excitotoxic cell death," J. Neurobiol., 23:1261-1276 (1992).
Sattayasai et al., "Morphology of quisqualate-induced neurotoxicity in the chicken retina," Invest. Ophthalmol. Vis. Sci., 28:106-117 (1987).
Quest Med., 33(2-3):75-85 (1980).
DeSantis, Jr. Louis
Kapin Michael A.
Langer Salomon
Shaver Paul F.
Synthelabo
Yeager Sally
LandOfFree
Use of polyamine antagonists for the treatment of glaucoma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of polyamine antagonists for the treatment of glaucoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of polyamine antagonists for the treatment of glaucoma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-725666