Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-10-16
2008-08-26
Gupta, Anish (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C514S013800, C514S014800, C530S300000, C530S317000, C530S325000, C530S327000, C530S333000
Reexamination Certificate
active
07417025
ABSTRACT:
The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-α2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-α2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.
REFERENCES:
patent: 6346512 (2002-02-01), Blaschuk et al.
patent: 98/08874 (1998-03-01), None
patent: 00/54805 (2000-09-01), None
patent: 02/46408 (2002-06-01), None
Rao Y, Wu X-F, Gariepy J, Rutishauser U, Siu C-H, Identification of a Peptide Sequence Invovled in Homophilic Binding in the Neural Cell Adhesion Molecule NCAM, Journal of Cell Biology, 1992, 118(4): 937-949.
Storms SD, Rutishauser U, A Role of Polysialic Acid in Neural Cell Adhesion Molecule Heterophilic Binding to Proteoglycans, Journal of Biological Chemistry, 1998, 273(4): 27124-27129.
J. S. Shin et al.: “Monoclonal Antibodies Specific forNeisseria meningitidisGroup B Polysaccharide and Their Peptide Mimotopes” Infection and Immunity, American Society for Microbiology, vol. 69, No. 5, p. 3335-3342, May 2001. XP-002228383.
Christian M. Hurpin et al.: “Bactericidal Activity of Two IgG2a Murine Monoclonal Antibodies with Distinct Fine Specificities for Group BNeisseria meningitidisCapsular Polysaccharide” Hybridoma, vol. 11, No. 6, p. 677-687, 1992. XP009004404.
Nielsen Claus Schafer
Rougon Genevieve
Schachner Melitta
Torregrossa Pascal
Centre National de la Recherche Scientifique
Gupta Anish
Ha Julie
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Schafer-N
LandOfFree
Use of poly-α2,8-sialic acid mimetic peptides to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of poly-α2,8-sialic acid mimetic peptides to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of poly-α2,8-sialic acid mimetic peptides to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4007404