Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-06-09
1999-01-26
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530399, A61K 3818
Patent
active
058638920
ABSTRACT:
A method of accelerating corneal wound healing in the corneal anterior stroma and/or improving the quality of wound healing in a mammal comprises: (1) providing an ophthalmically compatible solution of platelet-derived growth factor; and (2) applying the solution to the cornea of a mammal at the time of or subsequent to occurrence of a corneal wound in a quantity sufficient to accelerate clinically detectable healing, the healing being accelerated through proliferation of epithelial cells and/or keratocytes of the cornea stimulated by application of the platelet-derived growth factor to the cornea. The platelet-derived growth factor can be selected from the group consisting of the AA isoform, the AB isoform, the BB isoform, and mixtures thereof. A preferable form of platelet-derived growth factor is a recombinantly-derived refolded B-chain homodimer of 119 amino acids, having the amino acid sequence of SEQ ID NO: 1. The concentration of platelet-derived growth factor in the solution can be from about 10 .mu.g/ml to about 1000 .mu.g/ml, preferably from about 50 .mu.g/ml to about 500 .mu.g/ml, and most preferably about 100 .mu.g/ml.
REFERENCES:
patent: 4939135 (1990-07-01), Robertson et. al.
patent: 4983580 (1991-01-01), Gibson
patent: 5013714 (1991-05-01), Lindstrom et al.
patent: 5034375 (1991-07-01), Antoniades et. al.
Gartry et al., "Excimer Laser Photorefractive Keratectomy," Ophthalmology vol. 99, No. 8, 1992, p. 1212.
Van Mellaert et al., "On the Safety of 193-Nanometer Excimer Laser Refractive Corneal Surgery," Refractive & Corneal Surgery vol. 8, 1992, pp. 235-238.
Lohmann et al., "Plasmin-and Plasminogen-Activator Inhibitors After Excimer Laser Photorefractive Keratectomy: New Concept in Prevention of Postoperative Myopic Regression and Haze,"Refractive & Corneal Surgery, vol. 9, 1993, pp. 301-302.
Arshinoff, et al., "The Use of Topical Nonsteroidal Anti-inflammatory Drugs in Excimer Laser Photorefractive Keratectomy," Third American Intnl. Congress on Cataract, IOL and Refractive Surgery, 1993, pp. 1-21.
Nakada et al., "Effect of pdgf, igf and egf on corneal epithelial wound healing and reinnervation," Investigative Ophthalmology and Visual Science (4 Abstract Issue) vol. 31, 1990, St. Louis, p. 54.
Hersh et al., "Effect of Platelet-Derived Growth Factor on Cultures Keratocytes and Its Uptake by the Cornea," Investigative Opthalmology and Visual Science vol. 29, 1988, St. Louis, p. 313.
Hoppenreijs et al., "Effects of Platelet-Derived Growth Factor (PDGF) on Wounded Human Corneal Endothelium in Organ Culture,"X Intnl. Congress of Eye Research, vol. 55, No. S1, 1992, p. S99.
Stern, et al., "A Multilevel Approach to the Evaluation of Platelet Derived Growth Factor (PDGF) on Rabbit Corneal Wound Healing.," X Intnl. Congress of Eye Research, vol. 55, No. S1, 1992, p. S98.
Banks, Allen R., "The Role of Growth Factors in Tissue Repair II, Epidermal Growth Factor", Chapter 10, Molecular and Cellular Biology of Wound Repair, 1986, pp. 253-263.
Fox, Gary M., "The Role of Growth Factors in Tissue Repair III, Fibroblast Growth Factor", Chapter 11, Molecular and Cellular Biology of Wound Repair, 1986, pp. 265-271.
Adelmann-Grill, B, et al. "Chemotactic migration of normal dermal fibroblasts toward epidermal growth factor and its modular by platelet-derived growth factor and transforming growth factor-beta, "Eur. J. Cell. Biol., 51-322-326, 1990.
Cromack, Douglas T., et al., "Current Concepts in Wound Healing: Growth Factor and Macrophage Interaction," Journal of Trauma, 30:S129-133, 1990.
Antoniades, Harry N., et.al., "Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in sknin epithelial cells and PDGF mRNA in connective tissue fibroblasts, " Proc. National. Acad. Sci USA, 88:565-569 1991.
Ross, R., et. al., "Platelet-derived growth factor and its role in health and disease," Philos. Trans. R. Soc. Lond. Biol. 327:327:155-169, 1990.
Sun et al., Nature, vol. 269, (5628), pp. 489-493, Oct. 1977, Medline: 78010468.
Bennett et al., Am. J. Surg., vol. 166, pp. 74-81, 1993.
Kunkle et al., Invest. Ophthalmol., Visual Sci., vol. 32(4), p. 1159, 1991.
Nicolson Margery A.
Stern Michael E.
Wheeler Larry A.
Allergan Inc.
Amgen Inc.
Sayala Chhaya D.
LandOfFree
Use of platelet derived growth factor in ophthalmic wound healin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of platelet derived growth factor in ophthalmic wound healin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of platelet derived growth factor in ophthalmic wound healin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1450461