Use of placental growth factor for treating ischemic muscle...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C424S093100, C424S093200

Reexamination Certificate

active

07727971

ABSTRACT:
The present invention relates to prevention and treatment of strokes and ischemic diseases and to post-ischemic therapeutic treatment. The invention furthermore relates to the use of a growth factor or nucleic acids ensuring increased expression of a growth factor for treating, more particularly restoring the function of ischemic tissue, in particular muscles such as myocardium and skeletal muscles.

REFERENCES:
patent: 5919899 (1999-07-01), Persico et al.
patent: 7105168 (2006-09-01), Carmeliet et al.
patent: 2 332 373 (1999-06-01), None
patent: WO 97/14307 (1997-04-01), None
patent: WO 98/00493 (1998-01-01), None
patent: WO 98/07832 (1998-02-01), None
patent: WO 98/49300 (1998-11-01), None
patent: WO 99/40197 (1999-08-01), None
Chiocca et al, Gene Therapy for Nuerological Disorders and Brain Tumors, Edited by E. Antonio Chiocca, Humana Press, p. 191-203, 1998.
Eck et al Goodman & Gilman's The Pharmacological basis of Therapeutics, McGraw-Hill, New York, NY. pp. 77-101.
Tio et al, Human Gene Therapy, 10: 2953-2960, 1999.
Khan et al, Gene Therapy, 10: 285-291, 2003.
Autiero et al., “Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Fik1,”Nat. Med. 9(7):936-43 (2003).
Autiero et al., “Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders,”J. Thromb. Haemost. 1(7):1356-70 (2003).
Breier et al., “Expression of Vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation,”Development114(2):521-32 (1992).
Cao et al., “In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor,”J. Clin. Invest. 98(11):2507-11 (1996).
Carmeliet et al., “Abnormal blood vessel development and lethality in embryos lacking a single.VEGF allele,”Nature380(6573):435-9 (1996).
Carmeliet et al., “Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164and VEGF188,”Nat. Med. 5(5):495-502 (1999).
Carmeliet et al., “Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions,”Nat. Med. 7(5):575-83 (2001).
Carmeliet, “VEGF gene therapy: stimulating angiogenesis or angioma-genesis?”Nat. Med. 6(10):1102-3 (2000).
Conn et al., “Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line,”Proc. Natl. Acad. Sci. USA87(4):1323-7 (1990).
Connolly et al., “Human vascular permeability factor: isolation from U397 cells,”J. Biol. Chem. 264(33):20017-24 (1989).
Connolly et al., “Tumor vascular permeability factor stimulates endothelial cell growth and anglogenesis,”J. Clin. Invest. 84(5):1470-8 (1989).
Connolly, “Vascular permeability factor: a unique regulator of blood vessel function,”J. Cell. Biochem. 47(3):219-23 (1991).
Couffinhal et al., “Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor In ApoE −/− mice,”Circulation99(24):3188-98 (1999).
Deindl et al., “Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit,”Circ. Res. 89(9):779-86 (2001).
DiSalvo et al., “Purification and characterization of a naturally occurring vascular endothelial growth factor—placenta growth factor heterodimer,”J. Biol. Chem. 270(13):7717-23 (1995).
Ferrara et al., “The vascular endothelial growth factor family of polypeptides,”J. Cell. Biochem. 47(3):211-8 (1991).
Ferrara and Henzel, “Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells, ”Biochem. Biophys. Res. Commun. 161(2):851-8 (1989).
Folkman and Shing, “Anglogenesis,”J. Biol. Chem. 267(16):10931-4 (1992).
Frelin, “VEGF: a mediation of hypoxic angiogenesis,”Medicine Sciences13(6-7):886-92 (1997).
Gospodarwicz et al., “Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived foillculo stellate cells,”Proc. Natl. Acad. Sci. USA86(19):7311-5 (1989).
Hariawala et al., “VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts,”J. Surg. Res. 63(1)77-82 (1996).
Henry et al., “The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis,”Circulation107(10):1359-65 (2003).
Isner and Asahara, “Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization,”J. Clin. Invest. 103(9):1231-6 (1999).
Klagsbrun and D'Amore, “Regulators of angiogenesis,”Annu. Rev. Physiol. 53:217-39 (1991).
Levy et al., “An endothelial cell growth factor from the mouse neuroblastoma cell line NB41,”Growth Factors2(1):9-19 (1989).
Luttun et al., “Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1,”Nat. Med. 8(8):831-40 (2002).
Maglione et al., “Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor,”Proc. Natl. Acad. Sci. USA88(20):9267-71 (1991).
Michael, “Relationship of skeletal muscle atrophy to functional status: a systematic research review,”Biol. Res. Nurs. 2(2):117-31 (2000).
Ngo et al., “Computational complexity, protein structure prediction, and the Levinthal paradox,”The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14 (eds. Merz and Le Grand), pp. 491-5, Birkhäuser, Boston (1994).
Pipp et al., “VEGFR-1-selective VEGF homologue PIGF Is arteriogenic: evidence for a monocyte-mediated mechanism,”Circ. Res. 92(4):378-85 (2003).
Pettit and Gombotz, “The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals,”Trends Biotechnol. 16(8):343-9 (1998).
Tjwa et al., “VEGF and PIGF: two pleiotropic growth factors with distinct roles in development and homeostasis,”Cell Tissue Res. 314(1):5-14 (2003).
Wells, “Additivity of mutational effects in proteins,”Biochemistry29(37):8509-17 (1990).

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