Use of piperine to increase the bioavailability of nutritional c

Details Use of piperine to increase the bioavailability of nutritional c Use of piperine to increase the bioavailability of nutritional c

1995-02-24

1996-07-16

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

4241951, 424423, 424430, 424434, 424443, 424451, A61F 202, A61F 606, A61K 970, A61K 948

Patent

active

055365060

ABSTRACT:
A new composition and method for the improvement of gastrointestinal absorption and systemic utilization of nutrients and nutritional supplements, wherein the composition comprises an extract from the fruit of Piper containing a minimum of 98% of pure alkaloid piperine. The method comprises oral, topical, or parenteral administration of the compositions of the invention. A new process for the extraction and purification of piperine is also disclosed.

REFERENCES:
patent: 4284657 (1981-08-01), Stanton
Wood et al., "Piperine determination in pepper (Piper nigrum L) and its oleoresins--a reversed phase high-performance liquid chromatographic method", Overseas Dev. Nat. Resource Inst., Flavour Fragrance J., 3(2), 55-64, (1988.
Kawada et al., "Rapid Communication", Proceedings of the Society for Experimental Biology and Medicine, 188, 229-233 (1988).
Bano et al., "Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers", Eur. J. Clin. Pharmacol (1991) 41:615-617.
Bano et al,. "The Effect of Piperine on Pharmacokinetics of Phenytoin in Healthy Volunteers", Planta Medica, vol. 17, 568-569 (1987).
Atal et al., "Biochemical Basis of Enhanced Drug Bioavailability by Piperine: Evidence that Piperine is a Potent Inhibitor of Drug Metabolism", Journal of Pharmacol. & Experimental Therapeutics, vol. 232, No. 1, (1985).
Zutshi et al., "Influence of Piperine on Rifampicin Blood Levels In Patients of Pulmonary Tuberculosis", JAP1, (1985) vol. 33, No. 3.
Dahanukar et al., "Influence of Trikatu Powder on Rifampicin Bioavailability", Indian Drugs, Jul. 1983, 402-404.
Atal et al., "Scientific Evidence on the Role of Ayurvedic Herbals on Bioavailability of Drugs", Short Communication, (1980).

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