Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation

Details Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation

1981-12-09

1983-03-15

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424251, 424319, A61K 31195, A61K 31495, A61K 31505

Patent

active

043767729

ABSTRACT:
Piperazinyl-imidazo[1,2-a]pyrazines and their acid addition salts are selective .alpha..sub.2 -adrenergic receptor antagonists and are thereby useful for treating sedation caused by antihypertensive drug therapy.

REFERENCES:
patent: 4078063 (1978-03-01), Lumma et al.
patent: 4081542 (1978-03-01), Lumma et al.
patent: 4082844 (1978-04-01), Lumma et al.
patent: 4242344 (1980-12-01), Lumma
Birch et al., Br. J. Pharmacol., 68, 107p (1979).
Drew et al., Br. J. Pharmacol., 67, 133 (1979).
Clineschmidt et al., Arch. Int. Pharmacodyn. Ther., 244, 231 (1980).
Autret et al., Eur. J. Pharmacol., 12, 319 (1977).

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