Use of phosphotriester intermediates for preparation of function

Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease – Antinuclear

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435 7, 436500, 436528, 436536, 436816, 436817, 436829, G01N 3354, G01N 3378

Patent

active

044800410

ABSTRACT:
A method of forming an analyte-functionalized liposome for use in immunoassay techniques employs a phosphotriester intermediate of a phospholipid derivatized with the desired analyte in a process of forming a liposome which is functionalized on its outer surface with the analyte and which carries an enzyme marker. The method is also used to functionalize the liposome with a ligand which acts as a leash between the analyte and the liposome. Liposomes produced by the method include penicillin-G-functionalized liposome.

REFERENCES:
patent: 3850578 (1974-11-01), McConnell
patent: 4255411 (1981-03-01), Lim
patent: 4342826 (1982-08-01), Cole
patent: 4372745 (1983-02-01), Mandle

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