Use of phosphoprotein patterns for diagnosis of neurological and

Details Use of phosphoprotein patterns for diagnosis of neurological and Use of phosphoprotein patterns for diagnosis of neurological and

1987-04-07

1989-10-17

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435267, 435268, 435272, 436 63, 436 64, 436 87, 436177, 530352, 530402, 530412, 530812, 530817, 530828, 530839, 2041801, 2041828, C12Q 148, C07G 1700, C07G 1500, C07K 312

Patent

active

048746940

ABSTRACT:
A diagnostic method for neurological and psychiatric disorders utilizes the cerebrospinal fluid incubated in the presence of 32-P labelled ATP and an appropriate protein kinase. After termination of the reaction, a sample is applied to gels for electrophoresis. Subsequent autoradiography results in a disease-specific protein pattern that can be used for diagnosis of disorders such as Alzheimer disease, Huntington disease, Parkinson disease, dystonia ataxia, schizophrenia, epilepsy brain tumors, brain irradiation, head trauma, and acute and chronic encephalitic and vascular disease.

REFERENCES:
patent: 4594319 (1986-06-01), Sharma
patent: 4599305 (1986-07-01), Witte et al.
patent: 4666829 (1987-05-01), Glenner et al.
Nestler et al., Science, vol. 225, (1984), pp. 1357-1364.

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