Use of phenylpropanolamine as a mucus secretogogue in the upper

Details Use of phenylpropanolamine as a mucus secretogogue in the upper Use of phenylpropanolamine as a mucus secretogogue in the upper

1992-06-04

1993-11-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424451, 424457, 424464, 424468, 514849, 514853, A61K 908, A61K 920, A61K 948

Patent

active

052600734

ABSTRACT:
The present invention encompasses the novel method of using .+-.phenylpropanolamine to induce mucous secretion in the upper airways of persons afflicted with sinusitis or otitis media characterized by retention of thickened respiratory secretions. These methods comprise administering to such person a safe and effective amount of .+-.phenylpropanolamine. It also encompasses certain novel oral compositions consisting essentially of l(-)-norephedrine and a pharmaceutically-acceptable excipient base.

REFERENCES:
patent: 4083950 (1978-04-01), Duvall et al.
patent: 4619934 (1986-10-01), Sunshine et al.
patent: 4738966 (1988-04-01), Sunshine et al.
patent: 4749697 (1988-06-01), Sunshine et al.
patent: 4749711 (1988-06-01), Sunshine et al.
patent: 4749720 (1988-06-01), Sunshine et al.
patent: 4749721 (1988-06-01), Sunshine et al.
patent: 4749722 (1988-06-01), Sunshine et al.
patent: 4749723 (1988-06-01), Sunshine et al.
patent: 4818541 (1989-04-01), Sanderson
patent: 4839354 (1989-06-01), Sunshine et al.
patent: 4840962 (1989-06-01), Sunshine et al.
patent: 4894233 (1990-01-01), Sharma
Gallagher, J. T. et al., "The composition of tracheal mucus and the nervous control of its secretion in the cat," 192 Proc. R. Soc. Long. B., 49-76 (1975).
Wells, U. et al., "Lateral Nasal Gland Secretion in the Anaesthetized Dog," 374 J. Physiol., 359-374 (1986).
Phipps, R. J. et al., "Effect of Alpha-Adrenergic Stimulation on Mucus Secretion and on Ion Transport in Cat Trachea In Vitro.sup.1-3," 121 American Review of Repiratory Disease, 359-365 (1980).
Phipps, R. J. et al., "Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro," 63 Clinical Science, 23-28 (1982).
WPI66-07742F/00, date Mar. 1962, France (Eng. Abs*).
WPI84-152447/25, date Feb. 1984, Belgium (Eng. Abs*).
WPI66-00688F/00, date Jan. 1968, Great Britain (Abs*).
WPI20269 K/09, date Jun. 1981, Germany (Eng. Abs*).
WPI66-19205F/00, date Jun. 1959, Japan (Eng. Abs*).
L. Lasagna, Phenylpropanolamine: A review. (1988) (pp. 7-12; 24-25; 28-29; 138; 302; 317; 320-345).
M. Bende and L. Laurin, "Sympathomimetrics in Nasal Allergy," J. Otorhinolaryngol. Relat. Spec. 48(4):238-242), 1986.
S. Loth and M. Bende, "The Effect of Phenylpropanolamine on Nasal Secretion and Nasal Airway Resistance After Histamine Challenge in Man." Clin. Otolaryngol. 10(1):15-19 (Feb.) 1985.
Drug Facts and Comparisons, 1990 ed. Copyright 1989 published by J. B. Lippincott Co., St. Louis, Mo.

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