Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1995-04-03
1997-12-23
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 93, 436173, 514443, 514463, 514730, 549 31, 549433, A61B 5055
Patent
active
057004480
ABSTRACT:
The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.
REFERENCES:
patent: 4499095 (1985-02-01), Rosseels et al.
patent: 4656026 (1987-04-01), Coffman et al.
patent: 4863717 (1989-09-01), Keana
patent: 4882327 (1989-11-01), King
patent: 4957925 (1990-09-01), Gubin et al.
patent: 4985063 (1991-01-01), Fischer et al.
patent: 5028614 (1991-07-01), Liu et al.
patent: 5066807 (1991-11-01), Anzeveno et al.
patent: 5223510 (1993-06-01), Gubin et al.
patent: 5264204 (1993-11-01), Cacheris et al.
patent: 5362477 (1994-11-01), Moore et al.
Skowronska-Ptasinska et al., J. Organometallic Chemistry 141(2):149-156 (1977).
Lurie et al., Journal of Magnetic Resonance, 76, 366-370, 1988.
Grucker, Magnetic Resonance in Medicine, 14, 140-147, 1990.
Nagamura et al., Chemical Abstracts, 96, 10, Abstract No. 70290a, 1981.
Fessenden et al., Chemical Abstracts, 94, 22, Abstract No. 183019w, 1981.
Clough et al., Chemical Abstracts, 83,10, Abstract No. 88194p, 1975.
Wadsworth et al., J. Org. Chem., 51, 24, 4639-4644, 1986.
Mueller-Warmuth et al., Chemical Abstracts, 74, 8, Abstract No. 35176s, 1970.
Kalyanaraman et al., The Journal of Biological Chemistry, 264, 19, 11014-11019, 1989.
Andersson Sven
Golman Klaes
Rise Frode
Wikstrom Hakan
Wistrand Lars-Goran
Hollinden Gary E.
Nycomed Imaging AS
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