Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1991-12-30
1993-10-19
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
4241951, 514824, A61K 3123
Patent
active
052545857
DESCRIPTION:
BRIEF SUMMARY
The present invention relates in general terms to a novel therapeutic indication for known products and relates essentially to the use of peroxidized lipids for the preparation of a drug intended for the treatment of circulatory insufficiencies, and especially male sexual asthenia, by local application.
It is known that many people suffer from circulatory insufficiency of arterial or venous origin, which is often chronic.
Circulatory insufficiencies are sometimes of a local and benign nature, manifesting themselves for example by a feeling of painful numbness at the finger ends caused by severe cold (tingling), or else of heaviness in the lower limbs.
Circulatory insufficiencies can also manifest themselves in much more serious forms associated with an arrest of the blood circulation (ischemia), which is capable of causing localized necrosis. Arterial or venous leg ulcers, for example, are the result of such a circulatory insufficiency and are a clinical manifestation of insufficient irrigation of the superficial and deep tissues by the blood flow.
Numerous treatments have hitherto been proposed for overcoming these insufficiencies.
Thus it has already been recommended to use numerous vasodilative or vasoprotective products by oral or percutaneous administration, often by perfusion.
However, these products have many undesirable side-effects, so their use is restricted to the most serious cases of circulatory insufficiency.
Moreover, tissue revascularization products have so far never been proposed which are totally devoid of toxicity and capable of being applied locally and whose use could be envisaged for the treatment of circulatory insufficiency at all stages.
It has been discovered that certain peroxidized lipids have a very great efficacy in tissue revascularization when applied locally, and that these products do not cause any undesirable side-effects; it is this discovery which forms the basis of the present invention.
Thus the present invention relates to the use of peroxidized lipids, having a degree of peroxidation of between 50 and 200 milliequivalents per kilogram, preferably of between 50 and 150 milliequivalents per kilogram, for the preparation of a pharmaceutical composition intended for the treatment of circulatory insufficiencies, and in particular male sexual asthenia, by local application.
It was observed that a significant efficacy was not obtained with a degree of peroxidation of less than 50 milliequivalents per kilogram.
Furthermore, detrimental free radicals were generated with a degree of peroxidation of more than 200 milliequivalents per kilogram.
The peroxidized lipids used according to the invention are known products prepared from lipids, for example by saturation with oxygen and intense and controlled exposure to ultraviolet rays.
These products have been described especially in the following documents: BSM No. 2330 M; EP-A-293 535; FR-A-2 591 112; EP-A-225 831; EP-A-225 832; EP-A-225 833; EP-A-226 506; FR-A-2 461 744; FR-A-2 539 142 and EP-A-117 962.
In these documents of the prior art, these compounds are presented as being capable of use in the treatment of certain complaints, especially in rheumatology or traumatology, or else as cicatrizing products.
However, the teaching of this state of the art contained neither an indication nor even a remote suggestion of the use of these products for the preparation of a pharmaceutical composition intended for the treatment of circulatory insufficiencies.
It has been found, totally surprisingly and unexpectedly, that the local application of these products is capable of increasing, to a remarkable extent, not only the superficial blood flow but also the subcutaneous or deep blood flow. In particular, it has been found that these products cause a doubling of the blood flow compared with that prior to the application of the product. This increase in blood flow is substantially greater than that obtained with conventional vasodilative products employed in perfusion, and appears to be the result of a different mechanism of action.
The p
Laboratoires Carilene
Rollins John W.
LandOfFree
Use of peroxidized lipids for the preparation of a drug intended does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of peroxidized lipids for the preparation of a drug intended, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of peroxidized lipids for the preparation of a drug intended will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1352122