Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1999-05-06
2000-10-17
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
514529, 514 11, 514 19, A61K 31045, A61K 31215, A61K 3800
Patent
active
061333247
ABSTRACT:
Perillyl alcohol and its monoterpene derivatives used alone or in combination with existing immunosuppressive agents, such as cyclosporine A and azathioprine, to provide methods and compositions which reduce allograft rejection in organ transplant patients.
REFERENCES:
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Woodrow, M., et al., "P21.sup.ras and Calcineurin Synergize to Regulate the Nuclear Factor of Activated T cells," J. Exp. Med., 178:1517-1522 (1993).
Phillips, L.R., et al., "Pharmacokinetics of Active Drug Metabolites After Oral Administration of Perillyl Alcohol, an Investigational Antineoplastic Agent, to the Dog," Drug Metabolism and Disposition, v.23, No. 7, pp. 676-680 (1995).
First, M.R., "An Update on New Immunosuppressive Drugs Undergoing Preclinical and Clinical Trials: Potential Applications in Organ Transplantation," Am. J. Kidney Diseases, vol. 29, No. 2, pp. 303-317 (1997).
Imagawa David K.
Ming-Sing Si
Criares Theodore J.
Kim Jennifer
The Regents of the University of California
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