Use of perfluoroalkyl-containing metal complexes as contrast...

Details Use of perfluoroalkyl-containing metal complexes as contrast... Use of perfluoroalkyl-containing metal complexes as contrast...

2008-03-18

2008-03-18

Jones, Dameron L. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009360, C424S009321, C424S009361, C424S009362, C424S009300, C424S009100

Reexamination Certificate

active

10616511

ABSTRACT:
The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s as contrast media in MR imaging for visualization of intravascular thrombi.

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Yu Xin et al., “High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent,” Magnetic Resonance in Medicine, Dec. 2000, pp. 867-872, vol. 44, No. 6, XP001155744, ISSN: 0740-3194, the entire document.

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