Use of peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S300000

Reexamination Certificate

active

07141541

ABSTRACT:
We claim a therapeutic method of inducing programmed cell death comprising administering to a recipient a peptide of 10–25 amino acids, comprising the sequence: (KR)xxYxxx(F/Q)L(L/M) wherein x is any amino acid.

REFERENCES:
patent: 6610508 (2003-08-01), Hentze et al.
patent: WO 94/18345 (1994-08-01), None
patent: WO 96/13614 (1996-05-01), None
patent: WO 98/39357 (1998-09-01), None
Haghighat et al. (1996) The elF4G-elF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase, J. Virol. vol. 70, No. 12, pp. 8444-8450.
De Benedetti, et al., “Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology,”Proc. Natl. Acad. Sci. USA87: 8212-8216 (Nov. 1990).
Dostie, et al., “Nuclear Eukaryotic Initiation Factor 4E (elF4E) Colocalizes with Splicing Factors in Speckles,”The Journal of Cell Biology148(2): 239-245 (2000).
Fletcher, et al., “4E Binding Proteins Inhibit the Translation Factor eIF4E without Folded Structure,”Biochemistry37: 9-15 (1998).
Flynn, et al., “Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway,”Federation of European Biochemical Societies389: 162-166 (1996).
Fukuchi-Shimogori, et al., “Malignant Transformation by Overproduction of Translation Initiation Factor eIF4G,”Cancer Research57: 5041-5044 (1997).
Green, et al., “Mitochondria and Apoptosis,”Science281: 1309-1312 (1998).
Hentze, Matthias W., “elF4G: A Multipurpose Ribosome Adapter?”Science, 275(Jan.): 500-501 (1997).
Kroemer, Guido, “The proto-oncogene Bcl-2 and its role in regulating apoptosis,”Nature Medicine3(6): 614-620 (1997).
Li, et al., “Clinical Outcome in Stage I to III Breast Carcinoma and elF4E Overexpression,”Annals of Surgery227(5): 756-763 (1998).
Li, et al., “Overexpression of Eukaryotic Initiation Factor 4E (elF4E) in Breast Carcinoma,”American Cancer Society79: 2384-2390 (1997).
Minamikawa, et al., “Mitochondrial Permeability Transition and Swelling Can Occur Reversibly without Inducing Cell Death in Intact Human Cells,”Experimental Cell Research246: 26-37 (1999).
O Nathan, et al., “Detection of the proto-oncogene elF4E in surgical margins may predict recurrence in head and neck cancer,”Oncogene15: 579-584 (1997).
Okuno, et al., “Bcl-2 Prevents Caspase-independent Cell Death,”The Journal of Biological Chemistry273(51): 34272-34277.
Pyronnet, et al., “Human eukaryotic translation initiation factor 4G (elF4G) recruits Mnkl to phosphorylate elF4E,”EMBO Journal, 18(1): 270-279 (1999).
Rosenwald, et al., “Elevated Levels of Cyclin D1 Protein in Response to Increased Expression of Eukaryotic Initiation Factor 4E,”Molecular and Cellular Biology Dec.: 7358-7363 (1993).
Rosenwald, et al., “Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis,”Oncogene18: 2507-2517 (1999).
Rousseau, et al., “The elF4E-binding proteins 1 and 2 are negative regulators of cell growth,”Oncogene13: 2415-2420 (1996).
Shantz, et al., “Regulation of Ornithine Decarboxylase in a Transformed Cell Line That Overexpresses Translation Initiation Factor eIF-4E,”Cancer Research56: 3265-3269 (1996).
Sonenberg, et al., “The mRNA5' cap-binding protein elF4E and control of cell growth,”Current Opinion in Cell Biology, 10: 268-275 (1998).
Sonenberg, et al., “Translational control of apoptosis: An essential role for initiation factor 4E in preventing oncogene-dependent cell death,”Biology 28abstract (1997).
Susin, et al., “Molecular characterization of mitochondrial apoptosis-inducing factor,”Nature397: 441-446 (1999).
Wolf, et al., “Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Preteinases,”The Journal of Biological Chemistry274(29): 20049-20052 (1999).
Xiang, et al., “BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases,”Proc. Natl. Acad. Sci. USA93: 14559-14563 (1996).
Polunovsky et al. Abstract. “Translational Control of Apoptosis: An Essential Rold for Initiation Factor 4E in Preventing Oncogene-Dependent Cell Death,”Proceedings of the American Association For Cancer Research Annual.1997, vol. 38, pp. 624.
Altmann et al. “A novel inhibitor of cap-dependent translation initiation in yeast: p. 20 competes with eIF4G for binding to eIF4E,”Embo Journal.1997, vol. 16, No. 5, pp. 1114-1121.
Lawrence, J.C. et al. “PHAS/4E-BPs as regulators of mRNA translation and cell proliferation.”Tibs Trends in Biochemical Science.1997, vol. 22, No. 9, pp. 345-349.
Renschler et al. “B-Lymphoma Cells Are Activated by Peptide Ligands of the Antigen Binding Receptor or by Anti-Idiotypic Antibody to Induce Extracellular Acidification,”Cancer Research.Dec. 1, 1995, vol. 55, pp. 5642-5647.

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