Use of peptide derivatives for the preparation of medicaments in

Details Use of peptide derivatives for the preparation of medicaments in Use of peptide derivatives for the preparation of medicaments in

1993-04-09

1997-10-14

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514 7, 530331, 548535, A61K 3805

Patent

active

056772815

ABSTRACT:
The invention relates to the use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16.
These peptide derivatives are in accordance with the formula: ##STR1## in which R.sup.1 is an optionally substituted aralkyl group, R.sup.2 is Pro, Hyp, thiazolidine or dehydroproline, R.sup.3 is H or an alkyl radical, R.sup.4 is an alkyl group or the side chain of an amino acid, R.sup.5 and R.sup.6 can be H, NH.sub.4 + or metals and R.sup.7 is H or CH.sub.3.
N-(phenylethylphosphonyl)-Gly-Pro-aminohexanoic acid and N-(phenylethyl phosphonyl)-Ala-Pro-aminohexanoic acid are examples of effective derivatives.

REFERENCES:
patent: 4558034 (1985-12-01), Galardy et al.
A. Yiotakis, et al, Eu. J. Biochem., vol. 172, pp. 761-766 (1988).
Dive et al., Eur. J. Biochem. 191 (1990) pp. 685-693.

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