Use of parvovirus for brain tumor therapy

Details Use of parvovirus for brain tumor therapy Use of parvovirus for brain tumor therapy

2007-02-20

2007-02-20

Campell, Bruce R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

C435S005000, C435S320100

Reexamination Certificate

active

10426709

ABSTRACT:
Treatment of brain tumors by a composition including parvovirus, e.g., parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. Also described is the use of a parvovirus for the preparation of a pharmaceutical composition for the treatment of a brain tumor. Tumors for which the compositions and methods of the invention have particular utility include glioma, medulloblastoma and meningioma.

REFERENCES:
Fulci et al. Frontiers in Bioscience, 2003, vol. 8, pp. e346-360.
Telerman et al. Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 8702-8706.
Oshshima T. et al. J. Gene. Virol. 1998, vol. 79, pp. 3067-3071.
Lauran Neergaard, “Altered Cold Virus Kills Brain Tumors in Mice,” Journal of the National Cancer Institute, May 7, 2003, pp. 1-3.

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