Use of parthenolide derivatives as antileukemic and...

Details Use of parthenolide derivatives as antileukemic and... Use of parthenolide derivatives as antileukemic and...

2007-12-25

2007-12-25

Owens, Amelia A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S321000, C514S232800, C514S254110, C549S299000, C548S526000, C544S153000, C544S378000

Reexamination Certificate

active

10888274

ABSTRACT:
Compounds of the formula having anti-tumor activity, wherein R1and R2are as described herein

REFERENCES:
patent: 2003/0125373 (2003-07-01), Nakshatri et al.
patent: 2004/0229936 (2004-11-01), Hsieh et al.
Ruangrungsi, N et al ‘Studies on Thai medicianal plants Ix. Constituents ofMichelia rajaniana.Two new germacranolide amides’ CA 110:151284 (1989).
See Ross, JJ et al, Low concentration of the feverfew component parthenolide inibit in vitro growth of tumor lines in a cytostatic fashion, PMID: 10193202 (1999).
Wen, J et al, Oxidative Stress-mediated Apoptosis, The Anticancer Effect of the Sesquiterpene Lactone Parthenolide, J. Biological Chem, 277(41), pp. 38954-38964 (2002).
Abduazimov, BK et al, Modification of the Sesquiterpane Lactone Arteannuin B and Antimicrobial Activities of the Products Obtained, Chemistry of Natural Compounds, 33(5), (1997) 554-557.
Cory and Cory, “Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells”Anticancer Research2002, 22, 3805-9.
Cory and Cory, “Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation”Anticancer Research, 2001, 21, 3807-11.
Gelfanov et al., “Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with aft/erk leads to p65 nuclear factor κB-mediated antiapoptosis involving c-IAP2”Blood, 2000, 98, 2508-17.
Kang et al., “Enhancement of 1α,25-dihydroxyvitamin D3-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-κB activity”Brit. J. Pharmacol.2002, 135, 1235-44.
Song et al., “A new sesquiterpene lactone from Tsoongiodendron odorum chun”J. Asian. Nat. Prod. Res.2001, 3, 285-91.
Wen et al., “Oxidative stress-mediated apoptosis”J. Biol. Chem.2002, 277, 38954-38964.
U.S. Appl. No. 60/459,769, filed Apr. 02, 2003, Hsieh et al.
Hwang et al., “Synthesis and anti-viral activity of series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system”Bioorganic and Medicinal Chemistry14: 83-91 (2006).

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