Use of paramagnetic compounds to measure temperature and pH in v

Details Use of paramagnetic compounds to measure temperature and pH in v Use of paramagnetic compounds to measure temperature and pH in v

1996-08-19

1998-05-19

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 9363, 514184, 514492, 514502, 514836, 1286534, 128654, 436173, A61B 5055

Patent

active

057532079

ABSTRACT:
A method for measuring temperature and/or pH in vivo using paramagnetic compounds, e.g., lanthanide complexes, in conjunction with NMR has been developed. The chemical shift of the nuclear spin in these complexes can then be correlated to temperature. This non-invasive temperature measurement method is particularly useful in monitoring temperature of cancerous tissue during hyperthermic treatment to destroy the cancerous tissue or tumor.

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