Use of PAK inhibitor for the treatment of a joint disease

Details Use of PAK inhibitor for the treatment of a joint disease Use of PAK inhibitor for the treatment of a joint disease

2008-04-29

2008-04-29

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C514S014800, C514S04400A, C514S002600, C435S194000, C435S094000

Reexamination Certificate

active

10893025

ABSTRACT:
The invention refers to the use of a p21-activated kinase (PAK) inhibitor for the treatment of a joint disease such as osteoarthritis or rheumatoid arthritis or for the treatment of a joint pain and the use of PAK as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.

REFERENCES:
patent: 5698445 (1997-12-01), Abo et al.
patent: 6013464 (2000-01-01), Abo et al.
patent: 6383734 (2002-05-01), Marshall et al.
patent: WO 00/60062 (2000-10-01), None
Zhao et al (A Conserved Negative Regulatory region in alpha-PAK: Inhibition of PAK Kinase Reveals Their Morphological Roles Downstream of Cdc42 and Rac1. American Society of Microbiology. 1998. p. 2153-2163.
Nheu et al The K252A Derivatives , inhibitors for the PAK/MLK kinase family, selectively block the growth of HAS transformants. The Cancer Journal Jul./Aug. 2002, vol. 8 Issue 4, p. 328-336.

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