Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-06-29
1994-12-20
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514558, 514666, A01N 3308, A61K 3113, A61K 3119, A61K 3120
Patent
active
053746589
ABSTRACT:
Described herein is the use of a substantially pure form of an oxidized polyamine, and especially spermine dialdehyde, in the treatment of tissue grafts or other organs for transplantation. The compounds and treatment are especially useful in treating grafts for bone marrow transplants, whether they be allogeneic or autograft transplants.
REFERENCES:
Wang et al "Ex vivo spermine dialdehyde treatment prevents lethal 6VHD in a murine bone marrow transplantation model" Bone Marrow Transplantation (1990) 6, 235-242.
Gaugas, Polyamines in Biomedical Research (1980) John Wiley & Sons Chapter 22 pp. 343-362.
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Bachrach, U. and E. Rosenkovitch, Applied Microbiology, vol. 23, No. 2, (1972) pp. 232-235: "Effective Oxidized Spermine and Other Aldehydes on the Infectivity of Vaccina Virus".
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Allen et al., Nature vol. 267 (1967) pp. 623-625: "Identification of a Thymic Inhibitor (Chalone) of Lymphocyte Transformation as a Spermine Complex".
Bachrach et al., Advances in Polyamine Research vol. 3, Edited by C. M. Caldarera et al., Raven Press, New York, 1981: "Polyamine Biosynthesis and Metabolism in Transformed Human Lymphocytes".
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GB patent application GB 2017492.
Nutter Nathan M.
O'Gorman Carmella
Ortho Phamaceutical Corporation
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