Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1990-09-18
1992-12-15
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3113
Patent
active
051717549
ABSTRACT:
This invention relates to the use of oxidized polyamines, and especially aminoaldehydes such as spermine bisaldehyde both in vitro and in vivo to elicit an immunosuppressive response in living cells. It also relates to the therapeutic application of these compounds to induce an immunosuppressive response in living organism.
REFERENCES:
Alarcon et al., Archives of Biochemistry and Biophysics 94 (1961).
Tabor, Celia and Sanford and Rosenthale, "Pharmacology of Spermine and Spermidine--Some Effects on Animals and Bacteria" Aug. 1955.
Tabor et al, "Identification of the Aminoaldehydes Produced by the Oxidation of Spermine and Spermidine with Purified Plasma Amine Oxidase", Journal of Biological Chemistry, vol. 239, 2194-2203 (1964).
Fukami et al., Biochemical and Biophysical Research Communications, vol. 28, No. 1, (1967): "Phagocidal Action of Oxidized Spermine and Its Analogues".
K. Kremzner, Leon and Donald H. Harter, Biochemical Pharmacology, vol. 19, pp. 2541-2550, (1969), "Antiviral Activity of Oxidized Polyamines and Aldehydes".
Bachrach, U., and F. Don, Journal of General Virology, vol. 11, (1) 1-9,: (1971): "Inactivation of Myxoviruses by Oxidized Polymines".
Kimes, Brian and David R. Morris, Biochimica et Biophysica Acta, vol. 228 (1971), pp. 223-234 (1970): "Preparation and Stability of Oxidized Polymines".
Bachrach, U. and E. Rosenkovitch, Applied Microbiology, vol. 23, No. 2, (1972) pp. 232-235: "Effective Oxidized Spermine and Other Aldehydes on the Infectivity of Vaccina Virus".
Nishimura, et al., Agricultural Biological Chemistry, vol. 39 (A) 1663-1666 (1975): "Phagocidal Activity of the Hydrolyzate of Acetal Derivatives of Oxidized Spermine and its N, N'Dimethyl Analogue".
Byrd et al., Nature vol. 267, (1977) pp. 621-623: "Synthetic Polyamines Added to Cultures Containing Bovine Sera Reversibly Inhibit In Vitro Parameters of Immunity".
Allen et al., Nature Volume 267 (1967) pp. 623-625: "Identification of a Thymic Inhibitor (Chalone) of Lymphocyte Transformation as A Spermine Complex".
Byrd et al., Advances in Polyamine Research, vol. 2, (1978) pp. 71-83: "Influence of Synthetic Polyamines on In Vitro Responses of Immunocompetent Cells".
Joseph M. Gaugas, Polyamines in Biomedical Research (1980) J. M. Gaugas, Editor John Wiley & Sons: "Biogenic Diamines and Polyamines in Support and in Inhibition of Lymphocyte Proliferation".
Bachrach et al., Advances in Polyamine Research vol. 3, Edited by C. M. Caldarera et al., Raven Press, N.Y., 1981: "Polyamine Biosynthesis and Metabolishm in Transformed Human Lymphocytes".
Abbott, A. C. and C. C. Bird, vol. 115, No. 2, (1983), pp. 727-742, Biochemical and Biophysical Research Communications: "Cyytolethal Sensitivity of Human Lymphoid Cells to Glucocorticoids and Oxidized Polyamines".
Labib, R. and Thomas B. Tomasi, European Journal of Immunology vol. 11, pp. 266-269 (1981): "Enzymatic Oxidation of Polyamines, Relationship to Immunosuppressive Properties".
Frolik, et al., Archives of Biochemistry and Biophysics, vol. 230, No. 1, Apr., pp. 93-102 (1984): "Inhibition of Transforming Growth Factor-Induced Cell Growth and Soft Agar by Oxidized Polyamines".
Smith, et al., Biochemical Society Transactions, pp. 326-329, vol. 13; "Inhibition of Cell Proliferation by Polyamines Does Not Depend on the Cytotoxicity of Acrolein" (1985).
A. Ferrante, Immunology, vol. 54, pp. 785-789 (1985): "Inhibition of Human Neutrophil Locomotion by the Polyamine Oxidase-Polyamine System".
Israel et al., vol. 16, No. 1, (1973): "Synthesis and Anti-Tumor Evaluation of the Presumed Cytotoxic Metabolytes of Spermine and N,N'-bis (3-amino propyl) Nonane-1,9-diamene".
GB Patent Application GB 2017492: (Oct. 1979).
Fay Zohreh A.
Matthews Gale F.
Ortho Pharmaceutical Corporation
Waddell Frederick E.
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