Use of oxidized lipoproteins for differentiation of...

Details Use of oxidized lipoproteins for differentiation of... Use of oxidized lipoproteins for differentiation of...

2007-08-21

2007-08-21

Davis, Ruth A (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of co-culturing cells

C435S372000, C435S377000, C424S283100, C424S093700

Reexamination Certificate

active

10482480

ABSTRACT:
The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to the medium, in a predetermined amount, at least one fraction of oxidized lipoproteins selected among oxidized very low density lipoproteins (VLDLs) and/or oxidized intermediate density lipoproteins (IDLs) and/or oxidized low density lipoproteins (LDLs). The precursor cells are preferably monocytes.

REFERENCES:
patent: 5776978 (1998-07-01), Bruzzese
patent: 5998452 (1999-12-01), Ohi et al.
patent: 6039946 (2000-03-01), Strahilevitz
Perrin-Cocon et al, “Oxidized low Density Lipoprotein Promotes mature Dendritic Cell Transition from Differentiating Monocytes”, J. Immunology, Oct. 2001; 167(7):3785-91.
Hamilton et al, “Oxidized LDL Can Promote Human Monocyte Survival”, Arterioscler. Thromb. Vasc, Biol., 2000; 20;2329-2331.

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