Use of oversulfated polysaccharides as inhibitors of HIV

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Reexamination Certificate

active

10484883

ABSTRACT:
The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

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Leali D et al., “Fibroblast growth Factor-2 antagonist activity and angiostatic capacity of sulfatedEscherichia coliK5 polysaccharide derivatives,” Journal of Biological Chemistry, Oct. 12, 2001, pp. 37900-37908, vol. 276, No. 41, XP001077702, ISSN: 0021-9258, abstract, American Society of Biological Chemists, Baltimore, MD, US; & 'Online! Journal of Biological Chemistry Papers in Press, Jul. 25, 2001, XP002226476, Retrieved from the Internet: <URL:http://www.jbc.org/cgi/content/abstract/M105163200v1> 'retrieved on Jan. 8, 2003! The whole document.
Casu Benito et al., “Heparin-like compounds prepared by chemical modification of capsular polysaccharide from E. coli K5,” 1994, pp. 271-284, vol. 263, No. 2, ISSN: 0008-6215, cited in the application, abstract.

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