Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-05-03
2011-05-03
Weddington, Kevin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S428000, C514S635000, C514S866000
Reexamination Certificate
active
07935723
ABSTRACT:
A method for improving glucose control by administering metformin in combination with a DPP-IV inhibitor to a patient in need thereof, in an amount sufficient to control the glucose level over an extended period of time.
REFERENCES:
patent: 3174901 (1965-03-01), Sterne
patent: 6166063 (2000-12-01), Villhauer
patent: WO01/52825 (2001-07-01), None
Ahren, Bo et al., “The DDP-4 inhibitor, LAF237, improves glycemic control in patients with type 2 diabetes (T2DM) inadequately treated with metmorfin” Jun. 2004, XP002344251, ADA 64th Scientific sessions Orlando, FL.
Thomson Scientific Meeting Previews, 2004 XP002344252.
Yasuda N et al.: “Enhanced secretion of glucagon-like peptide 1 by biguanide compounds” Biochemical and Biophusical Research Communications, Academic PRES, San Diego, CA, US ISSN: 0006-291X p. 781, p. 783, right-hand column.
Yasuda N et al.: “Synergistic effects of combination of DPPIV inhibitor with metformin on glycemic control, food intake and weight gain in Zucker fa/fa rats.” Diabetologia, vol. 46, No. Supplement 2, Aug. 2003, p. A 28f4, XP009053536 & 18th Congress of TE International Diabetes Feeration; Paris, France; Aug. 24-29, 2003 ISSN: 012-186X abstract.
Dilworth & Barrese LLP
Novartis Pharma AG
Pokalsky, Esq. Ann R.
Weddington Kevin
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