Use of oral interleukin-6 as therapy for hemorrhagic shock

Details Use of oral interleukin-6 as therapy for hemorrhagic shock Use of oral interleukin-6 as therapy for hemorrhagic shock

1996-12-20

1999-04-20

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 2, 514 8, 514921, A61K 3820

Patent

active

058956476

ABSTRACT:
A method for ameliorating the effects of hemorrhagic shock in a subject consists of locally administering to the gut of the subject, at a selected time during the period of from about 5 hours before blood loss to about 5 hours after blood loss, a therapeutic amount of a cytokine.

REFERENCES:
patent: 5154921 (1992-10-01), Sager et al.
patent: 5188828 (1993-02-01), Goldberg et al.
patent: 5296353 (1994-03-01), Ochoa et al.
patent: 5426181 (1995-06-01), Lee et al.
patent: 5723120 (1998-03-01), Brakenhoff
Baqar, S.et al. Dec. 1993. Modulation of Mucosal Immunity against Campyloter jejuni by Orally administered Cytokines. Antimicrobial Agents and Chemotherapy, vol.37, No. 12, p.2688.
Rollwagen, F.M. et al., Use of Oral Cytokines to Alleviate Bacterial Translocation from the Gut Following Hemorrhage, The 9th International Congress of Immunology, Jul. 23-29, 1995, San Francisco, California, U.S.A., Abstract Book p. 136, Abstract No. 801.
VanSnick, J. Interleukin-6: an overview. Ann. Rev. Immunol. 8:253. 1990.
Ryffel, B., M.J. Mihatsch and G. Woerly. Pathology induced by IL-6. Int. Rev. Exp. Pathol. 34:79-89, 1993.
Heinrich, P.C., J.V. Castell and T. Andus. Interleukin-6 and the acute phase response. Biochem. J. 265:621-636, 1990.
Rollwagen FM, Li YY, Pacheco ND, Nielsen TB: Systemic bacteraemia following haemorrhagic shock in mice: alleviation with oral Interleukin-6, Cytokine vol. 8 No.2:121-129; 1996.
Rollwagen, F.M. et al., Orally Administered IL-6 as Prophylaxis for Sepsis Following Hemorrhagic Shock, Choque 96, Nov. 14, 1996, Sao Paulo, Brazil, Abstract No. S-6.
Cytokines in Health and Disease, ed Remick ed, 2nd ed, 1997, pp. 581-589.
Immunology, ed Kuby, 1992, p. 266.
Natanson et al., Annals of Internal Medicine, v. 120(9) 1994, p. 771.

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