Use of .omega.-conotoxin analogs for treating retinal and optic

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 13, 514912, 530324, 530325, 530857, 424 7804, 424427, A61K 3800

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059655348

ABSTRACT:
The invention is directed to the use of .omega.-conotoxins for the prevention and treatment of retinal or optic nerve head damage in humans. Compositions and methods are disclosed.

REFERENCES:
patent: 4447356 (1984-05-01), Olivera et al.
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 4950739 (1990-08-01), Cherksey et al.
patent: 5051403 (1991-09-01), Miljanich et al.
patent: 5189020 (1993-02-01), Miljanich et al.
patent: 5432155 (1995-07-01), Olivera et al.
Benveniste, "Elevation of the Extracellular Concentrations of Glutamate and Asparate in Rat Hippocampus During Transient Cerebral Ishcemia Monitored by Intracerebral Microdialysis", Journal of Neurochemistry, vol. 43, No. 5, pp. 1369-1374 (1984).
Choi, D., et al.; "Excitotoxic Cell Death", Journal of Neurobiology, vol. 23, No. 9, pp. 1261-1276 (1992).
Choi, D.; "Glutamate Neurotoxicity and Diseases of the Nervous System", Neuron, vol. 1, pp. 623-634 (1988).
Cruz, L., et al.; "Characterization of the .omega.-Conotoxin Target. Evidence for Tissue-Specific Heterogeneity in Calcium Channel Types", Biochemistry, vol. 26, pp. 820-824 (1987).
Cruz, L., et al.; "Conus Venoms: A Rich Source of Neuroactive Peptides", J. Toxicol.-Toxin Reviews, vol. 4, No. 2, pp. 107-132 (1985).
David, P., et al.; "Involvement of Excitatory Neurotransmitters in the Damage Produced in Chick Embryo Retinas by Anoxia and Extracellular High Potassium", Exp. Eye Res., vol. 46, pp. 657-662 (1988).
Deshpande, J., et al.; "Flunarizine, a Calcium Entry Blocker, Ameliorates Ischemic Brain Damage in the Rat", Anesthesiology, vol. 64, No. 2, pp. 215-224 (1986).
Jones, O., et al.; "Localization and Mobility of .omega.-Conotoxin --Sensitive Ca.sup.2+ Channels in Hippocampal CA1 Neurons", Science, vol. 244, pp. 1189-1193 (1989).
McCleskey, E., et al.; ".omega.-Conotoxin: Direct and persistent blockafe of specific types of calcium channels in neurons but not muscle", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 4327-4331 (1987).
Olney, J., et al.; "The Role of Specific Ions In Glutamate Neurotoxicity", Neuroscience Letters, vol. 65, pp. 65-71 (1986).
Reynolds, I., et al.; "Brain voltage-sensitive calcium channel subtypes differentiated by .omega.-conotoxin fraction GVIA", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 8804-8807 (1986).
Sauter, A., et al.; "Treatment of Hypertension with Isradipine Reduces Infarct Size following Stroke in Laboratory Animals", The American Journal of Medicine, vol. 86 (suppl 4A), pp. 130-133 (1989).
Scatton, B., et al.; "Eliprodil Hydrochloride", Drugs of the Future, vol. 19, No. 10, pp. 905-909 (1994).
Sheardown, M., et al.; "2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia", Science, vol. 247, pp. 571-574 (1990).
Sher, E. et al.; ".omega.-Conotoxin binding and effects on calcium channel function in human neuroblastoma and rat pheochromocytoma cell lines", FEBS Letters, vol. 235, No. 1,2, pp. 178-182 (1988).
Siesjo, "Calcium, Excitotoxins, and Brain Damage", NIPS, vol. 5, pp. 120-124 (1990).
Siliprandi, R., et al.; "N-methyl-D-asparate-induced neurotoxicity in the adult rat retina", Visual Neuroscience, vol. 8, pp. 567-573 (1992).
Sisk, D., et al.; "Histologic changes in the inner retina of albino rates following intravitreal injection of monosodium L-glutamate", Graefe's Arch Clin Exp Ophthalmol, vol. 223, pp. 250-258 (1985).
Smith, M., et al.; "Postischemic treatment with the .OMEGA.-conopeptide SNX 111 protects the rat brain against ischemic damage", J. Krieglstein, H. Oberpichler-Schwenk (Eds.) Pharmacology of Cerebral Ischemia, pp. 161-166 (1992).
Sucher, N. et al.; "N-methyl-D-asparate Antagonists Prevent Kainate Neurotoxicity in Rat Retinal Ganglion Cells in vitro", The Journal of Neuroscience, vol. 11, No. 4, pp. 966-971 (1991).
Tung, N., et al.; "A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick", Visual Neuroscience, vol. 4, pp. 217-223 (1990).
Valentino, K., et al.; "A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 7894-7897 (1993).

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