Use of nucleic acid analogues in the inhibition of nucleic acid

Details Use of nucleic acid analogues in the inhibition of nucleic acid Use of nucleic acid analogues in the inhibition of nucleic acid

1997-10-08

1999-10-26

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 536 245, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500

Patent

active

059726105

ABSTRACT:
The present invention relates to the use of nucleic acid analogues in blocking nucleic acid amplification procedures and to diagnostic and analytical techniques based thereon. Also included are kits for use in the conduct of nucleic acid amplification reactions.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4988617 (1991-01-01), Landegren et al.
Nielsen et al., Science, vol. 254, pp. 1497-1500, Dec. 6, 1991, "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide".
Meier et al., Angew. Chem. Int. Ed. Engl. vol. 31, No. 8, pp. 1008-1010, 1992, "Peptide Nucleic Acids (PNAs)--Unusual Properties of Nonionic Oligonucleotide Analogues".

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