Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-03
2007-04-03
Rawlings, Stephen L. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007210, C435S007230, C536S023500, C530S350000, C530S387700, C530S389700, C530S391300
Reexamination Certificate
active
10454764
ABSTRACT:
This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies capable of specifically binding to NRG4.
REFERENCES:
patent: 6825333 (2004-11-01), Kavanaugh et al.
patent: PCT/US00/22326 (2001-03-01), None
patent: WO 2001/14415 (2001-03-01), None
patent: WO 2003/101401 (2003-12-01), None
Dunn et al. (J. Pathol. 2004; 203: 672-680).
Falls et al. (Exp. Cell Res. 2003; 284: 14-30).
Harari et al. (Oncogene. 1999; 18: 2681-2689).
Gilmour et al. (Clin. Cancer Res. Dec. 2002; 8: 3933-3942).
Carraway and Burden, “Neuregulins and their receptors,”Current Opinion in Neurobiology, vol. 5, pp. 606-612, (1995).
Yarden and Sliwkowski, “Untangling the ErbB Signalling Network,”Nature Reviews, Molecular Cell Biology, vol. 2, pp. 127-137. (2001).
Meyer and Birchmeier, “Multiple essential functions of neuregulin in development,”Nature, vol. 378, pp. 386-390, (1995).
Carroll et al., “Expression of Neuregulins and their Putative Receptors, ErbB2 and ErbB3, Is Induced during Wallerian Degeneration,”The Journal of Neuroscience, 17.5, pp. 1642-1659, (1997).
Burden and Yarden, “Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis,”Neuron, vol. 18, pp. 847-855, (1997).
Lee et al., “Requirement for neuregulin receptor erbB2 in neural and cardiac development,”Nature, vol. 378, pp. 394-398, (1995).
Gassmann et al., “Abberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor,”Nature, vol. 378, pp. 390-394, (1995).
Carraway, “Involvement of the neuregulins and their receptors in cardiac and neural development,”BioEssays, vol. 18, pp. 263-266, (1996).
Tzahar et al., “ErbB-3 and ErbB-4 Function as the Respective Low and High Affinity Receptors of All Neu differentiation Factor/Heregulin Isoforms,” The Journal of Biological Chemistry, vol. 269, No. 40, pp. 25226-25233, (1994).
Pinkas-Kramarski et al., “ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network,”Molecular and Cellular Biology, vol. 18, No. 10, pp. 6090-6101, (1998).
Harari et al., “Neuregulin 4: a noval growth factor that acts through the ErbB-4 receptor tyrosine kinase,”Oncogenevol. 18, pp. 2681-2689, (1999).
Carraway III et al., “Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2
eu and erbB3*,”The Journal of Biological Chemistry, vol. 270, No. 13, pp. 7111-7116, (1995).
Morrissey et al., “Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2,”Proc. Natl. Acad. Sci., vol. 92, pp. 1431-1435, (1995).
Peles and Yarden, “Neu and its Ligands: From an Oncogene to Neural Factors,”BioEssays, vol. 15, pp. 815-824, (1993).
Marshall et al., “Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast,”Breast Cancer Research and Treatment, vol. 96, pp. 163-168, (2006).
Abraham Judith A.
Jefferson Anne B.
Kavanaugh W. Michael
Schleyer Siew C.
Alexander Lisa E.
Attwell Gwilym
Chiron Corporation
Harbin Alisa A.
Rawlings Stephen L.
LandOfFree
Use of NRG4, or inhibitors thereof, in the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of NRG4, or inhibitors thereof, in the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of NRG4, or inhibitors thereof, in the treatment of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3762157