Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-19
1998-07-28
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514312, 514313, 514314, A61K 3147
Patent
active
057863652
ABSTRACT:
The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of complications, in particular for the prophylaxis or treatment of portal hypertension, decompensation symptoms such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.
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Madeddu et al., Effects of Hoe, 140, a bradykinin B.sub.2 -receptor antagonist, on renal function in conscious normotensive rats, Br. J. Pharmacol., vol. 106:380-386 (1992).
Majima et al., High Sensitivity to Salt in Kininogen-Deficient Brown Norway Katholiek Rats, Hypertension, vol. 22 (5):705-714 (1993).
Bickel Martin
Heitsch Holger
Hropot Max
Wagner Adalbert
Wirth Klaus
Hoechst Aktiengesellschaft
Reamer James H.
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