Use of non-peptide bradykinin antagonists for the treatment or p

Details Use of non-peptide bradykinin antagonists for the treatment or p Use of non-peptide bradykinin antagonists for the treatment or p

1997-10-14

1999-09-14

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514367, 514299, 514300, 514247, 514259, 514396, 514399, 514415, 514395, A61K 3147, A61K 3144, A61K 31415, A61K 31505

Patent

active

059523468

ABSTRACT:
The invention relates to the use of non-peptide bradykinin antagonists for the production of pharmaceuticals for the prevention and treatment of Alzheimer's disease. Suitable Compounds are non-peptide bradykinin antagonists which inhibit the actions of the Alzheimer's protein amyloid (.beta./A4) in isolated endothelial cells, such as for example, fused heterobicyclic fluoroalkyl derivatives.

REFERENCES:
patent: 5212182 (1993-05-01), Musser et al.
patent: 5216165 (1993-06-01), Mobilio et al.
patent: 5385915 (1995-01-01), Buxbaum et al.
patent: 5438064 (1995-08-01), Mobilio et al.
Roth et al., Die Stereochemie sigmatroper 1.5-Wasserstoffverschiebungen, Chem. Ber., vol. 103: 426-439 (1970).
Kinig et al., Eine neue Amid-Schutzgruppe, Chem. Ber., vol. 103:2041-2051 (1970).
Konig et al., Umlagerung von quartaren Allyl-, Benzyl-und Propargyl-hydraziniumsalzen, Chem. Ber., vol. 103: 2052-2061 (1970).
Rogers, J., Inflammation as a Pathogenic Mechanism in Alzheimer's Disease, Arzneim.-Forsch./Drug Res., vol. 45(1): 439-442 (1995).
Asano et al., The identification of an orally active, nonpeptide bradykinin B.sub.2 receptor antagonist, FR173657, British Journal of Pharmacology, vol. 120: 617-624 (1997).
Nitsch et al., Regulation of APP Processing, Potential for the Therapeutical Reduction of Brain Amyloid Burdenthu.alpha. , Annals New York Academy of Sciences, vol. 77: 175-182 (1996).
Huang et al., Increased Inositol 1,4,5-Trisphosphate Accumulation Correlates with an Up-Regulation of Bradykinin Receptors in Alzheimer's Disease, Journal of Neurochemistry, vol. 64(2): 761-766 (1995).
Peterson et al., Altered Response of Fibroblasts From Aged and Alzheimer Donors to Drugs that Elevate Cytosolic Free Calcium, Neurobiology of Aging, vol. 9: 261-266 (1988).
Racchi et al., Bradykinin Induced Amyloid Precursor Protein Secretion In Fibroblasts From Alzheimer's Disease, Down's Syndrome And Control Donors, Soc. Neurosci. Abst., p. 1944, Nov. 1966.
Griesbacher et al., Fr173657, A New, Potent And Selective Nonpeptide Bradykinin Antagonist: In Vivo Studies, Naunyn-Schmiedeberg's Arch. Pharmacol., page r6, Sep. 1996.

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