Use of non-ionic cloud point modifiers to minimize nanoparticle

Details Use of non-ionic cloud point modifiers to minimize nanoparticle Use of non-ionic cloud point modifiers to minimize nanoparticle

1992-12-04

1994-09-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 2, 424 4, 424491, 424492, 424493, 424494, 424496, 424497, 424498, 424 5, 514970, 514971, 514975, A61K 914, A61K 954

Patent

active

053467027

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount-sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a non-ionic cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

REFERENCES:
patent: 5145684 (1991-01-01), Liversidge et al.

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