Use of non-competitive and selective GluR5 antagonists as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C514S616000

Reexamination Certificate

active

07488756

ABSTRACT:
This invention relates to the use of chemical compounds showing non-competitive and selective GluR5 antagonist or partial agonist activity for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.

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patent: WO 01/02367 (2001-01-01), None
patent: WO 01/92273 (2001-12-01), None
Hardman, J. G., editor-in-chief, Goodman & Gilman's The Pharmacologoical Basis of Therapeutics, Ninth Edition, 1996, pp. 461, 467, 485.
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Webster's II, New Riverside University Dictionary, 1988, pp. 933 and 944.
Stanfa, L.C., et al. Neuroscience, vol. 93, No. 4, pp. 1391-1398, 1999.
Kubo Kazou, et al. retrieved from CAPLUS, accession No. 1978:169910, Database accession No. 88:169910 & Yamanouchi Seiyaku Kenyu Hokohu (1977), vol. date 1974, No. 3, pp. 8-12.
Hirschelman R, et al. retrieved from CAPLUS, accession No. 1972:21025, Database accession No. 76:21025 & Pharmazie, vol. 26, No. 8, 1971, pp. 491-492.
Ueda, et al. Journal of Polymer Science. vol. 17, 1163-1173 (1979).

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