Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-12-01
1999-09-14
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
5142362, 514278, 514329, A61K 31675, A61K 31535, A61K 3144, A61K 31445
Patent
active
059523158
ABSTRACT:
The present invention provides methods for the treatment or prevention of bipolar disorder without concomitant therapy with other antidepressant or anti-anxiety agents which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.
REFERENCES:
patent: 5162339 (1992-11-01), Lowe, III
patent: 5496833 (1996-03-01), Baker et al.
patent: 5538982 (1996-07-01), Hagan et al.
patent: 5612337 (1997-03-01), Baker et al.
patent: 5716942 (1998-02-01), Dorn et al.
patent: 5719147 (1998-02-01), Dorn et al.
patent: 5728695 (1998-03-01), Harrison et al.
Aguiar, M., et al., Physiology & Behavior, 1996, 60(4) 1183-1186.
Barden, N., et al., J. Neurochem., 1983, 41, 834-840.
Brodin, E., et al., Neuropharmacology, 1987, 26(6) 581-590.
Brodin, E., et al., Neuropeptides, 1994, 26, 253-260.
Culman, J., et al., J. Physiol. Pharmacol., 1995, 73, 885-891.
Cutler, et al., J. Psychopharmacol, 1994, 8, A22, 87.
Elliott, P.J., Exp. Brain Res. UK, 1988, 73, 354-356.
F-D-C Reports-Prescription Pharmaceuticals and Biotechnology, Dec. 8, 1997, 59 (49), 10.
File, S.E., Pharm. Biochem. Behavior, 1997, 58, 3, 747-752.
Kramer, et al., Science, 1998, 281, 1640-1645.
Lowe, J., et al., Drug News Perspect, 1992, 5(4), 223.
Malek-Ahmadi, Neuroscience and Behavioral Reviews, 1992, 16, 365-359.
Rimon, R., et al., Biological Psychiatry, 1984, 19(4), 509-516.
Roccon, et al., Pharmacological Research, 1995, 31, 191.
Shaikh, M., et al., Brain Research, 1993, 625, 283-294.
Shirayama, Y., et al., Brain Researh, 1996, 739, 70-78.
Siegel, R., et al., Neurochem. Int., 1984, 6(6), 783-789.
Siegel, A., et al., Aggressive Behavior, 1995, 21, 49-62.
Teixeira, R., et al., European J. Pharm., 1996, 311, 7-14.
Vassout, et al., Neuropeptides, 1994, 26 (Suppl. 1), 38.
Wahlestedt, Science, 1998, 281, 1624-1625.
Wall Street Journal, Aug. 13, 1998, B1, col. 2.
Baker Raymond
Curtis Neil Roy
Elliott Jason Matthew
Harrison Timothy
Hollingworth Gregory John
Jarvis William R. A.
Merck Sharp & Dohme Ltd.
Rose David L.
Thies J. Eric
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