Use of nitrogen oxide species and adducts to inhibit skeletal mu

Details Use of nitrogen oxide species and adducts to inhibit skeletal mu Use of nitrogen oxide species and adducts to inhibit skeletal mu

1994-07-15

1996-12-10

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424718, 514 19, 5142228, 514259, 514365, 514419, 514423, 514557, 514561, 514562, 514563, 514645, 514665, A61K 3116, A61K 31195, A61K 3802, A61K 3805

Patent

active

055831010

ABSTRACT:
A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contractions of skeletal muscle, which comprises administering a skeletal muscle relaxing amount to an individual in need thereof of a compound selected from the group consisting of nitroxyl ion (NO.sup.-), nitrosonium ion (NO.sup.+), nitric oxide and nitric oxide adducts or providers. This invention also is directed to stimulating the contraction of muscles in a mammal by administering an effective amount of a nitric oxide synthase inhibitor.

REFERENCES:
patent: 4060652 (1977-11-01), Khromov-Borisov et al.
patent: 4440685 (1984-04-01), Walser et al.
patent: 4923898 (1990-05-01), Sunshine et al.
patent: 5190924 (1993-03-01), Konteatis et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5385937 (1995-01-01), Stamler et al.
Pediatric Research, vol. 35 (4 Part 2), issued Apr. 1994, Williams et al, "Induction and Characterization of Inducible Nitric . . . ", p. 61A, Abs. No. 350.

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