Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-03-11
1998-11-24
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514149, 514238, 514255, 514315, 514319, 514329, 514332, 514357, 514426, 514492, 514494, 514499, 514558, 514564, 514563, 514579, 514611, 514645, 514649, 514647, A61K 3113, A61K 3144, A61K 31495, A61K 31445
Patent
active
058407596
ABSTRACT:
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5212204 (1993-05-01), Keefer et al.
patent: 5234956 (1993-08-01), Lipton et al.
patent: 5650442 (1997-07-01), Mitchell et al.
Adams et al., "Electron-Affinic Sensitization," Radiation Research, 67, 9-20 (1976).
Andrade et al., "Inhibitore of Nitric Oxide Synthase Selectively Reduce Flow in Tumor-Associated Neovasculature," Br. J. Pharmacol., 107, 1092-1095 (1992).
Bedford et al., "Threshold Hypoxia: Its Effect on the Survival of Mammalian Cells Irradiated at High and Low Dose-Rates," Br. J. Radiol., 39, 896-900 (1966).
Bohn et al., "Oxygen and Oxidation Promote the Release of Nitric Oxide fron Sydnonimines," Journal of Cardiovascular Pharmacology, 14(Suppl. 11), s6-s12 (1989).
Coleman et al., "Phase I Trial of the Hypoxic Cell Radiosensitizer SR-2508: The Results of the Five to Six Week Drug Schedule," I.J. Radiation Oncology Biol. Phys., 12, 1105-1108 (1986).
DeGraff et al., "Evaluation of Nitroimidazole Hypoxic Cell Radiosensitizers in a Human Tumor Cell Line High in Intracellular Glutathione," I.J. Radiation Oncology Biol. Phys., 16, 1021-1024 (1989).
Feelisch et al., "On the Mechanism of NO Release from Sydnonimines," Journal of Cardiovascular Pharmacology, 14(Suppl. 11), s13-s22 (1989).
Feelisch, M., "The Biochemical Pathways of NItric Oxide Formation from Nitrovasodilators: Appropriate Choice of Exogenous NO Donars and Aspects of Preparation and Handling of Aqueous NO Solutions," J. Cardiovasc. Pharmacol., 17(Suppl. 3), s25-s33 (1991).
Gatenby et al., "Oxygen Distribution inSquamous Cell Carcinoma Metastases and its Relationship to Outcome of Radiation Therapy," I.J. Radiation Oncology Biol. Phys., 14, 831-838 (1988).
Hall et a., "Extreme Hypoxia: Its Effect on the Survival of Mammalian Cells Irradiated at High and Low Dose-Rates," Br. J. Radiol., 39, 302-307 (1966).
Hall, Eric J., "The Oxygen Effect and Reoxygenation," Radiobiology for the Radiologist, 4.sup.th Ed., 133-164 (1994).
Howard-Flanders, "Effect of Nitric Oxide on the Radiosensitivity of Bacteria," Nature, 180, 1191-1192 (1957).
Hrabie et al., "New Nitric Oxide-Releasing Zwitterions Derived form Polyamines," J. Org. Chem, 58, 1472-1476 (1993).
Ignarro Louis J., "Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide," Annu. Rev. Pharmacol. Texicol, 30, 535-560 (1990).
Keefer et al., "Complexes of Nitric Oxide with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide," Biology of Nitric Oxide, 2, Enzymology, Biochemistry, Immunology, pp. 153-156, Moncada et al., eds. Portland Press, Chapel Hill, NC (1992).
Maragos et al., "Complexes of NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide," J. Med. Chem., 34, 3242-3247 (1991).
Maragos et al., "Nitric Oxide/Nucleophile Complexes Inhibit the In Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release," Cancer Research, 53, 564-568 (1993).
Mitchell et al. "Cellular Glutathione by Diethyl Meleate or Buthionine Sulfoximine: No Effect of Glutathione Depletion on the Oxygen Enhancement Ratio," Radiation Research, 96, 442-428 (1983).
Mitchell et al., "Radiation Sensitisation by Nitric Oxide Releasing Agents," British Journal of Cancer, 74(Suppl. 27), s181-s184 (1996).
Morley et al., "Mechanism of Vascular Relaxation Induced by the Nitric Oxide (NO)/Nucleophile Complexes, a New Class of NO-Based Vasodilators," Journal of Cardiovascular Pharmacology, 21, 670-676 (1993).
Murayama et al., "Radiosensitization of Hypoxic HeLa S3 Cells In Vitro by a New Type of Radiosensitizer: Spermine and Spermidine amides with Nitro Groups," Int. J. Radiat. Biol., 44(5), 497-503 (1983).
Phillips et al., "Promise of Radiosensitizers and Radioprotectors in the Treatment of Human Cancer," Cancer Treatment Reports, 68(1), 291-302 (1984).
Phillips et al., "Variation in Sensitizing Efficiency for SR 2508 in Human Cells Dependent on Glutathione Content," I.J. Radiation Oncology Biol. Phys., 12, 1627-1635 (1986).
Powers-Tolmach, "A Mulitcomponent X-Ray Survival Curve for Mouse Lymphosarcoma Cells Irradiated In Vivo," Nature, 197, 710-711 (1963).
Russo et al., "The Effects of Cellular Glutathione Elevation on the Oxygen Enhancement Ratio," Radiation Reseach, 103, 232-239 (1985).
Siemann et al., "Characterization of Radiation Resistant Hypoxic Cell Subpopulations in KHT Sarcomas. (ii) Cell Sorting," Br. J. Cancer, 58, 296-300 (1988).
Song et al., Int. J. Rad. Oncol. Biol. Phys., 30(Suppl. 1), 208 (1994).
Stamler et al., "S-Nitrosylation of Proteins with Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds," Proc. Natl. Acad. Sci. USA, 89, 444-448 (1992).
Stamler et al., "Nitric Oxide Circulates an Mammalian Plasma as an S-Nitroso Adduct of Serum Albumin," British Journal of Cancer, IV(4), 7476-7677 (1992).
Thomlinson et al., "The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy," British Journal of Cancer, IV(4), 539-549 (1955).
Von Sonntag, C., "The Chemical Basis of Radiation Biology," The Chemical Basis of Radiation Biology, Taylor and Francic, eds., London(1987).
Wink et al., "DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors," Science, 254, 1001-1003 (1991).
Wood et al., "Modification of Energy Metabolism and Radiation Response of a Mutrine Tumour by Changes in Nitric Oxide Availability," Biochemical and Biophysical Research Communications, 192(2), 505-510 (1993).
Krishna Murali C.
Liebmann James E.
Mitchell James B.
Russo Angelo
Wink, Jr. David A.
MacMillan Keith D.
The United States of America as represented by the Department of
LandOfFree
Use of nitric oxide releasing compounds to protect noncancerous does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of nitric oxide releasing compounds to protect noncancerous , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of nitric oxide releasing compounds to protect noncancerous will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1702664