Use of neutral metalloendopeptidase inhibitors in the treatment

Details Use of neutral metalloendopeptidase inhibitors in the treatment Use of neutral metalloendopeptidase inhibitors in the treatment

1986-06-20

1988-06-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 17, A61K 3743

Patent

active

047496886

ABSTRACT:
The method of treating hypertension with neutral metalloendopeptidase (NMEP) inhibitors, NMEP inhibitors in combination with atrial peptides, and NMEP inhibitors in combination with angiotensin converting enzyme inhibitors, as well as pharmaceutical compositions therefor, are disclosed.

REFERENCES:
T. Baum et al., Eur. J. Pharm., 94 (1983), pp. 85-91.
M. Wyvratt et al., Med. Res. Rev., 5 (1985), pp. 483-531.
P. Needleman et al., N. Engl. J. Med., 314 (1986), pp. 828-834.
M. Cantin et al., Scientific Amer., 254 (1986), pp. 76-81.
B. P. Rogues et al., Eur. J. Biochem., 139 (1984), pp. 267-274.
R. A. Mumford et al., Biochem. Biophys. Res. Commun., 109 (1982), pp. 1303-1307.
B. P. Rogues et al., J. Med. Chem., 26 (1983), pp. 60-65.
B. P. Rogues, J. Med. Chem., 28 (1985), pp. 1158-1169.

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