Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1997-11-12
1999-01-12
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
568735, A61K 3105, C07C 3914
Patent
active
058590676
ABSTRACT:
Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 or 6-membered, optionally substituted heterocyclic rings wherein the heteroatom is oxygen; and wherein the ring system comprises 1-4 phenyl rings and wherein Ar can be linked to another Ar via a group X wherein the Ar is independently selected; where X is optionally substituted C.sub.1-20 alkylene, C.sub.2-20 alkenylene or C.sub.2-20 alkynylene; R is hydrogen; C.sub.1-20 alkenyl, C.sub.2-20 alkynyl, C.sub.2-20 alkanoyl, C.sub.2-20 alkynoyl, each of which can be optionally substituted; R.sub.1 is independently selected and is hydrogen; optionally substituted C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl; --COOR'--NR'R', halogen, --OR', --COR', --CONR'R', .dbd.O, --SR', --SO.sub.3 R', --SO.sub.2 NR'R', --SOR', --SO.sub.2 R', --NO.sub.2, --CN, glycoside, silyl; where R' is independently hyrogen; alkyl, alkenyl or akynyl each optionally substituted; and where two groups R.sub.1 can be joined; wherein the optional substituents are one or more independently selected from C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl; --COOR"--NR"R", halogen, OR", --COR", --CONR"R", --SR", .dbd.O, --SO.sub.3 R", --SO.sub.2 NR"R", --SOR", --SO.sub.2 ", --NO.sub.2, --CN; wherein R" is independently hydrogen, alkyl, alkenyl, or alkynyl; n=1, 2 or 3; m=1, 2, 3 or 4; or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for inhibiting the action of Ca.sup.2+ -ATPase enzymes. Certain compounds of formula (I) and 8-lavandulyl flavone pharmaceutical formulations are new.
REFERENCES:
patent: 4716252 (1987-12-01), Wagner et al.
Biochem. Soc. Trans., vol. 20, No. 3, 1992, 249S, M. Wictome et al., "Mechanism of action of Ca.sup.2+ -ATPase inhibitors"--entire document.
Biochem. Med. Metal. Biol., 45,2,209-215 (1991), Teo Tian-Seng et al., "Does Calmodulin Mediate Inhibition of Human Erythrocyte Ca.sup.2+ -Pumping ATPase by Myricetin"--entire document.
Biochem.J. (1991)273, 489-492, F.B. Davis et al., "Sex-dependent inhibition by retinoic acid of thyroid-hormone action on rabbit reticulocyte Ca.sup.2+ -ATPase activity"--entire document.
J. Biol. Chem., vol. 265, No. 19, 5 Jul. 1990, 10993-9, T. Kawashima et al., "Selective Inhibition by Lasalocid of Hydrolysis of the ADP-insensitive Phosphoenzyme in the Catalytic cycle of Sarcoplasmic Reticulum. Ca.sup.2+ -ATPase"--entire document.
Biochemistry, vol. 29, No. 12, 1990, 3091-3101, F. Michelangeli et al., Mechanism of Inhibition of the (Ca.sup.2+ -Mg.sup.2+)-ATPase by Nonylphenol--entire document.
Biochem. Pharmacology,. vol. 39, No. 4, 769-774, 1990, G. Vile et al., "Thiol Oxidation and Inhibition of Ca-ATPase by Adriamycin in Rabbit Heart Microsomes"--entire document.
J. Biol. Chem. vol. 264, No. 34, 5 Dec. 1989, 20339-43, J.H. Petretski et al., "Activation of Ca.sup.2+ Uptake and Inhibition of Reversal of The Sacroplasmic Reticulum Ca.sup.2+ Pump by Aromatic Compounds" entire document.
Contraception, vol. 39, No. 4, Apr. 1989, 431-45, U. Kanwar et al, "Gossypol inhibition of Ca.sup.++ uptake and Ca.sup.++ -ATPase in human ejaculated Spermatozoal plasma membrane vesticles"--entire document.
Biochemical Pharmacology, vol. 40, No. 8, 1990, 1877-1884, J.O. Malva et al., Action of Antiestrogens on The (Ca.sup.2+ +Mg.sup.2+)-ATPase and Na.sup.+ /Ca.sup.2+ exchange of brain contex membranes--entire document.
Chemical Abstracts, vol. 116, 1992, Abstract 148483u, Otsuka Pharmaceutical Factory, Inc., "Flavanone derivatives from Sophora leachiana" (&JP 3246291)--abstract.
Aust. J. Chem., 1968, 21,2989-99, M. Rasmussen et la., "Chemical Studies of the Proteaceae III".--formula (Ia) p. 2989.
Aust. J. Chem., 1970,23,147-83, D.D. Ridley et al., "Chemical studies of the Proteaceae IV". formulae (1)-(3) and (5)-(6) p. 148, p. 172 lines 23-35.
M. Windholz, Ed, The Merck Index, 10th Ed, published 1983 by Merck & Co, Inc. (Rahway, N.J.) especially monographs 39,1883, 2233, 2802, 3056, 3085, 3428, 4216, 4593, 5065, 5291, 5774, 6235, 7115 and 8056 especially Monographs 23, 863, 952, 1730, 2217, 2546, 2869, 3075, 3567, 3755, 3815, 5928, 7215 8164 and 8897.
Chem. Pharm. Bull, 34,5, 1986, 2094-2099, T. Ohmoto et al., "Inhibition of Adenosine 3',5'-cycle Monophosphate Phosphodiesterase by Componenets of Sophora flavescens Aiton". Kushenol A, Table I p. 2096.
Chem. Pharm. Bull., 37,.5, 1392-1395 (1989), T. Nikaido et al., Inhibition of Adenosine 3',5'-Eyclic Monophosphate Phospholiesterase by Flavonoids. III Compount 48, Table I p. 1393.
Phytochemistry, vol. 31, 1992, 999-1001, N. Ruangruagsi et al., "Three flavanones with a lavandulyl group in The roots of Sophora Exigua". entire document.
Phytochemistry, vol. 33, No. 1, 1993, 203-8, M. Iinuma et al., "Seven phenolic compounds in The roots of Sophora Exigua". entire document.
Physiological Reviews, vol. 71, No. 1, Jan. 1991, 129-153, E. Carafoli; "Calcium pump of the plasma membrane" p. 134 col. 2 lines 44-45 Quercetin entire document.
US,A, 2321620 (B.C. Pratt) 15 Jun. 1943 Example II, p. 2 col. 2 lines 59-73.
"Activation of Ca.sup.2+ Release from Sarcoplasmic Reticulum Vesicles by 4-Alkylphenols" by Troy James Beeler and Kenneth S. Gable. Archives of Biochemistry and Biophysics, vol. 301, No. 2, Mar., pp. 216-220, 1993.
"Modulation of the Activities of Membrane Enzymes by Cereal Grain Resorcinolic Lipids", Z. Naturforsch. 47c, 41-46 (1992); received Oct. 18, 1990/Apr. 16, 1991, by Arkadiusz Kozubek, Malgorzata Nietubyc, and Aleksander F. Sikorski.
"Modification of ATP regulatory function in sarcoplasmic reticulum Ca.sup.2+ -ATPase by hydrophobic molcules", by Herman Wolosker, Jorge H. Petreski and Leopoldo De Meis, Eur. J. Biochem. 193, 873-877-(1990).
"Effects of Cannabinoids on Cardiac Mocrosomal CaAtPase Activity and Calcium Uptake" by Fred G. Collins and Coryce O. Haavik Chemical Pharmacology, vol. 28, pp. 23-3-2306. 1979.
"Effect of Diethylstilbestrol and Related Compounds on the Ca.sup.2+ -Transporting ATPase of Sarcoplasmic Reticulum", Nov. 22, 1991 By Francisco Martinez-Azorin, Jose A. Teruel, Francisco Fernandez-Belda, and Juan C. Gomez-Fernandez, pp. 11923-11929.
"Characterisation of a novel Ca.sup.2+ pump inhibitor (bis-phenol) and its effects on intracellular Ca.sup.2+ mobilization", Biochimica et Biophysica Acta 1195 (1994) 252-258, by Graham R. Brown, et al., Received 22 Feb. 1994.
"Plant Antimutagenic Agents, 4. .sup.1 Isolation and Structure Elucidation of Maesol. An Inactive Constituent of Maesa SPP." by Monroe E. Wall, et al., Journal of Natural Products, vol. 51. No. 6, pp. 1226-1231, Nov.-Dec. 1988.
Duke Colin Charles
Li Qian
Roufogalis Basil Don
Aulakh Charanjit S.
Rotman Alan L.
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