Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1997-12-04
1999-11-09
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435975, 435 24, 435 18, 435 4, 435 72, 435 721, 435 723, C12Q 137, C12Q 134, G01N 3353
Patent
active
059812095
ABSTRACT:
The present invention relates to novel methods and kits for quantitating N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity in biological samples, including prostate biopsies, seminal fluid, ejaculate, prostatic fluid, blood, saliva, and urine, for the purpose of identifying and differentiating between prostate carcinoma, benign prostatic hyperplasia, and normal prostate.
REFERENCES:
patent: H1312 (1994-05-01), Coughlin et al.
patent: 4151172 (1979-04-01), Ondetti et al.
patent: 4168267 (1979-09-01), Petrillo, Jr.
patent: 4316896 (1982-02-01), Thorsett et al.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4374131 (1983-02-01), Petrillo, Jr.
patent: 4444765 (1984-04-01), Karanewsky et al.
patent: 4448772 (1984-05-01), Karanewsky
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4452791 (1984-06-01), Ryono et al.
patent: 4468519 (1984-08-01), Krapcho
patent: 4547324 (1985-10-01), Wong et al.
patent: 4555506 (1985-11-01), Karanewsky et al.
patent: 4560680 (1985-12-01), Ryono et al.
patent: 4560681 (1985-12-01), Karanewsky
patent: 4567166 (1986-01-01), Karanewsky et al.
patent: 4616005 (1986-10-01), Karanewsky et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4703043 (1987-10-01), Karanewsky et al.
patent: 4715994 (1987-12-01), Parsons et al.
patent: 4716155 (1987-12-01), Karanewsky et al.
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4849525 (1989-07-01), Weller, III et al.
patent: 4853326 (1989-08-01), Quash et al.
patent: 4867973 (1989-09-01), Goers et al.
patent: 4885283 (1989-12-01), Broadhurst et al.
patent: 4906779 (1990-03-01), Weber et al.
patent: 4918064 (1990-04-01), Cordi et al.
patent: 4937183 (1990-06-01), Ultee et al.
patent: 4950738 (1990-08-01), King et al.
patent: 4959493 (1990-09-01), Ohfume et al.
patent: 4962097 (1990-10-01), Parsons et al.
patent: 4966999 (1990-10-01), Coughlin et al.
patent: 4988681 (1991-01-01), Ishikawa et al.
patent: 4994446 (1991-02-01), SoKolovsky et al.
patent: 5030732 (1991-07-01), Morita et al.
patent: 5041644 (1991-08-01), Morita et al.
patent: 5047227 (1991-09-01), Rodwell et al.
patent: 5061806 (1991-10-01), Morita et al.
patent: 5093525 (1992-03-01), Weber et al.
patent: 5099063 (1992-03-01), Parsons et al.
patent: 5136080 (1992-08-01), Miller et al.
patent: 5140104 (1992-08-01), Coughlin et al.
patent: 5143908 (1992-09-01), Parsons et al.
patent: 5145990 (1992-09-01), Parsons et al.
patent: 5147867 (1992-09-01), Parsons et al.
patent: 5156840 (1992-10-01), Goers et al.
patent: 5162504 (1992-11-01), Horoszewicz
patent: 5162512 (1992-11-01), King et al.
patent: 5190976 (1993-03-01), Weber et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5242915 (1993-09-01), Ueda et al.
patent: 5262568 (1993-11-01), Weber et al.
patent: 5326856 (1994-07-01), Coughlin et al.
patent: 5336689 (1994-08-01), Weber et al.
patent: 5449761 (1995-09-01), Belinka, Jr. et al.
patent: 5474547 (1995-12-01), Aebischer et al.
patent: 5495042 (1996-02-01), Belinka, Jr. et al.
patent: 5508273 (1996-04-01), Beers et al.
patent: 5527885 (1996-06-01), Coughlin et al.
patent: 5538957 (1996-07-01), Tsaklakidis et al.
patent: 5672592 (1997-09-01), Jackson et al.
patent: 5698402 (1997-12-01), Luderer et al.
Stauch, B. et al., "The effects of N-acetylated alpha linked acidic dipeptidase (NAALADase) inhibitors on [.sup.3 H]NAAG catabolism in vivo," Neuroscience Letters, 100, p. 295-300 (1989).
Subasinghe, N. et al., "Synthesis of Acyclic and Dehydroaspartic Acid Analogues of Ac-Asp-Glu-OH and Their Inhibition of Rat Brain N-acetylated .alpha.-linked Acidic Dipeptidase (NAALA Dipeptidase)," J. Med. Chem., 33, p. 2734-2744, (1990).
Rothstein, J. et al., "Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis," Anals of Neurology, vol. 28, p. 18-25 (1990).
Slusher, B. et al., "Rat brain N-acetylated .alpha.-linked acidic dipeptidase activity," The J. of Biological Chemistry, vol. 265, No. 34, p. 21297-21301, (1990).
Tsai, G. et al., "Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis," Brain Research, 556, p. 151-161 (1991).
Coyle, J. et al., "N-acetyl-aspartyl glutamate," Excitatory Amino Acids, p. 69-77 (1990).
Meyerhoff, J. et al., "Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate," Brain Research, 593, p. 140-143 (1992).
Meyerhoff, J. et al., "Activity of a NAAG-hydrolyzing enzyme in brain may affect seizure susceptibility in genetically epilepsy-prone rats," Molecular Neurobiology of Epilepsy, p. 163-172 (1992).
Slusher, B. et al., "Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated .alpha.-linked acidic dipeptidase (NAALADase)," J. of Comp. Neurology, 315, p. 217-229 (1992).
Tsai, G. et al., "Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamergic pathways," J. of Chem. Neuroanatomy, 6, p. 277-292 (1993).
Tsai, G. et al., "Changes of excitatory neurotransmitter metabolism in schizophrenic brains," Salmon Lecturer of the New York Academy of Medicine, (Dec. 2-3, 1993).
Slusher, B. et al., "NAALADase: A Potential Regulator of Synaptic Glutamate," Biotech Update DuPont NEN, 9, p. 37-39 (1994).
Koenig, M. et al., "N-acetyl-aspartyl-glutamate (NAAG) elicits rapid increase in intraneuronal Ca.sup.2+ in vitro," NeuroReports, 5, p. 1063-1068 (1994).
Jackson, P. et al., "Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated .alpha.-linked acidic dipeptidase," J. of Medicinal Chemistry, (1995).
Vornov, J. et al., "Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia," J. of Neurochemistry, 65, p. 1681-1691 (1995).
Woods, D. et al., "Gender-linked injury after focal cerebral ischemia," Soc. For Neuroscience 1996 Abstract Form, (1996).
Bhardwaj, A. et al., "Striatal nitric oxide (NO) production is enhanced in focal cerebral ischemia: An in vivo microdialysis study," Soc. For Neuroscience 1996 Abstract Form, (1996).
Heston, W., "Bedeutung des prostataspezifischen Membranantigens (PSMA)," Urologe, 35, p. 400-407 (1996).
Carter, R. et al., "Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of neuropeptidase," Proc. Nat. Acad. Sci., 93, p. 749-753 (1996).
Carter et al; Proc. Natl. Acad. Sci. U.S.A. (1996), vol. 93(2), p. 749-753.
Lapidus Rena S.
Slusher Barbara S.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Leary Louise N.
Nath Gary M.
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