Use of N9 morpholino derivatives of 7,8-disubstituted guanines

Details Use of N9 morpholino derivatives of 7,8-disubstituted guanines Use of N9 morpholino derivatives of 7,8-disubstituted guanines

1995-01-17

1995-08-08

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

4352402, 43524025, A61K 31535

Patent

active

054399076

ABSTRACT:
Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.

REFERENCES:
patent: 3532695 (1970-10-01), Dvonch et al.
patent: 5011828 (1991-04-01), Goodman et al.
patent: 5093318 (1992-03-01), Goodman et al.

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