Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2005-06-13
2011-12-13
Lankford, Jr., Blaine (Department: 1651)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C435S366000, C435S374000, C435S325000
Reexamination Certificate
active
08075881
ABSTRACT:
The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells in cardiac indications.
REFERENCES:
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5602301 (1997-02-01), Field
patent: 5827735 (1998-10-01), Young et al.
patent: 5928943 (1999-07-01), Franz et al.
patent: 6090625 (2000-07-01), Abuljadayel
patent: 6387369 (2002-05-01), Pittenger et al.
patent: 6653134 (2003-11-01), Prockop et al.
patent: 6777231 (2004-08-01), Katz et al.
patent: 7056738 (2006-06-01), Prockop et al.
patent: 7229827 (2007-06-01), Kim et al.
patent: 7514074 (2009-04-01), Pittenger et al.
patent: 2002/0061587 (2002-05-01), Anversa
patent: 2002/0164794 (2002-11-01), Wernet
patent: 2003/0003090 (2003-01-01), Prockop et al.
patent: 2003/0059414 (2003-03-01), Ho et al.
patent: 2004/0235165 (2004-11-01), Prockop et al.
patent: 2005/0169896 (2005-08-01), Li et al.
patent: 2007/0003530 (2007-01-01), Pittenger et al.
patent: WO 95/14079 (1995-05-01), None
patent: WO 96/16163 (1996-05-01), None
patent: WO 99/16863 (1999-04-01), None
patent: WO 01/21766 (2001-03-01), None
patent: WO 01/21767 (2001-03-01), None
patent: WO 01/62901 (2001-08-01), None
Tosh D et al. 2002. Conversion of pancreatic cells to hepatocytes. Biochem Soc Trans 30: 51-55.
Reinecke H et al. 2002. Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol 34: 241-249.
Murry Ce et al. 2004. Hematopoietic stem cells do not transdifferentiate into cardiac mycytes in myocardial infarcts. Nature 428: 664-668.
Izadpanah et al., “Biologic Properties of Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissue” Journal of Cellular Biochemistry, 99:1285-1297 (2006).
Long et al., Neural Cell Differentiation in Vitro from Adult Human Bone Marrow Mesenchymal Stem Cells Stem Cells and Development, 14:65-69 (2005).
Moriscot et al., “Human Bone Marrow Mesenchymal Stem Cells Can Express Insulin and Key Transcription Factors of the Endocrine Pancreas Developmental Pathway upon Genetic and/or Microenvironmental Manipulation in Vitro” Stem Cells, 23:594-604 (2005).
Sanchez-Ramos et al., “Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro” Experimental Neurology, 164:247-256 (2000).
Lankford, Examiner, U.S. Patent and Trademark Office, Office Action dated Apr. 3, 2007, in related U.S. Appl. No. 11/238,234.
Bianco et al., “Stem cells in tissue engineering” Nature; 414:118-121 (2001).
Lovell-Badge et al., “The future for stem cell research” Nature; 414:88-91 (2001).
Donovan et al., “The end of the beginning for pluripotent stem cells” Nature; 414:92-97 (2001).
Spradling et al., “Stem cells find their niche” Nature, 414:98-104 (2001).
Hamilton, D., “The tissue bank's shakey underpinnings” Science; 257:869 (1992).
Soonpaa et al, “Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium” Science; 264:98-101 (1994).
Prockop, D., “Marrow stromal cells as stem cells for nonhematopoietic tissues” Science; 276:71-74 (1997).
Bjornson et al., “Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo” Science; 283:534-537 (1999).
Reyes et al., “Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells” Blood; 98:2615-2625 (2001).
Lowell, S., “Stem cells show their potential” Trends in Cell Biology; 10:210-211 (2000).
Asahara et al., “Stem cell therapy and gene transfer for regeneration” Gene Therapy; 7:451-457 (2000).
Steinhelper et al., “Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice” American Physiological Society; 0363-6135/90:H1826-34, 1990.
Koh et al., “Long-term survival of AT-1 cardiomyocyte grafts in syngeneic myocardium” American Physiological Society; 0363-6135/93:H1727-33, 1996.
Koh et al., “Differentiation and long-term survival of C2C12 myoblast grafts in heart” J. Clin. Invest.; 92;1548-54 (1993).
Koh et al., “Strategies for myocardial repair” J. Interven. Cardio.; 8:387-393 (1995).
Dewitt, N., “Nature insight. Stem cells” Macmillan Magazines Lts. 2001, p. 87.
Orlic, et al., “Bone marrow cells regenerate infarcted myocardium” Nature; 410:701-5 (2001).
Beltrami et al., “Evidence that human cardiac myocytes divide after myocardial infarction” N. Engl. J. Med.; 344:1750-7 (2001).
Kehat et al., “Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes” J. Clin. Invest.; 108:407-414 (2001).
Reyes et al., “Origin of endothelial progenitors in human postnatal bone marrow” J. Clin. Invest.; 109:1-10 (2002).
Smith, A., “Cell therapy: in search of pluripotency” Current Biology; 8:R802-804 (1998).
Reyes et al., “Characterization of multilineage mesodermal progenitor cells in adult marrow” Abstract No. 124, American Society for Hematology (2001).
Reyes et al., “Turning marrow into brain: generation of glial and neuronal cells from adult bone marrow mesencymal stem cells” Abstract No. 1676, American Society for Hematology (2001).
Reyes et al., “Skeletal smooth and cardiac muscle differentiation from single adult marrow derived mesodermal progenitor cells” Abstract No. 2610, American Society for Hematology (2001).
Reyes et al., “Endothelial cells generated from human marrow derived mesenchymal stem cells (MSC)” Abstract No. 2276, American Society for Hematology (2001).
Thompson, L., “Fetal transplants show promise” Science; 257:868-869 (1992).
Jiang et al., “Pluripotency of mesenchymal stem cells derived from adult marrow” Nature; 418:41-49 (2002).
Verfaillie, C. “Investigator Profile” Journal of Hematotherapy and Stem Cell Research; 11:441-444 (2002).
Verfaillie et al., “Stem cells: hype and reality” Hematology (Am Soc Hematol Educ Program); 369-391 (2002) PMID: 12446433 [PubMed—in process].
Verfailue, C.M., “Meeting Report on an NHLBI Workshop on ex vivo expansion of stem cells, Jul. 29, 1999, Washington D.C. National Heart Lung and Blood Institute” Exp. Hematol.; 28:361-4 (2000).
Pagen Westphal, S., “Adult bone marrow eyed as source of stem cells” Boston Globe, Jan. 24, 2002.
Pagen Westphal, S., “Ultimate stem cell discovered” New Scientist, Jan. 23, 2002.
Wade et al., “Scientists herald a versatile adult cell” The New York Times on the Web, Jan. 25, 2002.
Pittenger et al., “Multilineage potential of adult human mesenchymal stem cells” Science, U.S. American Associate for the Advancement of Science; 284:143-147 (1999).
Reyes et al., “Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells” Annals of the New York Academy of Science; 938:231-235, 2001.
Geissler et al., “Effective use of donor MHC class I gene therapy in organ transplantation: prevention of antibody-mediated hyperacute heart allograft rejection in highly sensitized rat recipients” Human Gene Therapy; 11:459-469 (1999).
Eglitis et al., “Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice” Proc Natl Acad Sci USA; 94:4080-4085 (1997).
Kopen et al., “Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains” Proc Natl Acad Sci USA; 96:10711-10716 (1999).
Lagasse et al., “Purified hematopoietic stem cells can differentiate into he
Furcht Leo T.
Reyes Morayma
Verfaillie Catherine M.
Lankford, Jr. Blaine
Regents of the University of Minnesota
Tarolli, Sundheim Covell & Tummino LLP
LandOfFree
Use of multipotent adult stem cells in treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of multipotent adult stem cells in treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of multipotent adult stem cells in treatment of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4257426