Use of MP52 or MP121 for the treatment and prevention of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S350000, C530S399000

Reexamination Certificate

active

07632808

ABSTRACT:
The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.

REFERENCES:
patent: 4886747 (1989-12-01), Derynck et al.
patent: 6531450 (2003-03-01), Hotten et al.
patent: WO 93/16099 (1993-08-01), None
Goldberg et al. Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science. Jun. 7, 2002;296(5574):1860-4.
Hotten et al. Cloning and expression of recombinant human growth/differentiation factor 5. Biochem Biophys Res Commun. Oct. 28, 1994;204(2):646-52.
Hoetten et al., “Cloning of a New Member of the TGF-β Family; A Putative New Activin βc Chain”, Biochemcial and Biophysical Research Communications, (1995), vol. 206, No. 2, pp. 608-613.
Krieglstein et al., “TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+toxicity”, The EMBO Journal, vol. 14, No. 4, pp. 736-742, 1995.

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