Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2007-07-17
2007-07-17
Woitach, Joseph (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S365100, C435S366000, C435S352000
Reexamination Certificate
active
10792571
ABSTRACT:
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
REFERENCES:
patent: 4912040 (1990-03-01), Kaufman et al.
patent: 4965199 (1990-10-01), Capon et al.
patent: 5773245 (1998-06-01), Wittrup et al.
patent: 5914315 (1999-06-01), Sprecher et al.
patent: 6136599 (2000-10-01), Cho
patent: 6333175 (2001-12-01), Glockshuber et al.
patent: 6348192 (2002-02-01), Chan et al.
patent: 6451597 (2002-09-01), Dees et al.
patent: 6583108 (2003-06-01), Tamburini et al.
patent: 2003/0194398 (2003-10-01), Tamburini et al.
patent: 679448 (1994-04-01), None
patent: 2237288 (1991-05-01), None
patent: WO 94/08012 (1994-04-01), None
patent: WO 97/33996 (1997-09-01), None
patent: WO 00/37099 (2000-06-01), None
Herlitschka et al. High expression of a B-domain deleted factor VIII gene in a human hepatic cell line. Journal of Biotechnology, vol. 61, pp. 165-173, 1998.
Michels et al. Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells. The Journal of Biological Chemistry. vol. 272, No. 52, pp. 33283-33289, Dec. 1997.
Ailor, et al.,Biotechnol. Bioeng., vol. 58, pp. 196-203 (1998).
Dunn, et al.,Biochem. Soc. Trans., vol. 23, p. 78S (1995).
Hsu, et al.,Protein Expr. Purif., vol. 5, pp. 595-603 (1994).
Hsu, et al.,Protein Expr. Purif., vol. 7, pp. 291-288 (1996).
Hsu, et al.,Biotechnol. Prog., vol. 13, pp. 96-104 (1997).
Ostermeier, et al.,J. Biol. Chem., vol. 271, pp. 10616-10622 (1996).
Robinson, et al.,BioTechnology, vol. 12, pp. 381-384 (1994).
Shusta, et al.,Nat. Bio-technol., vol. 16, pp. 773-777 (1998).
Wunderlich, et al.,J. Biol. Chem., vol. 268, pp. 24547-24550 (1993).
Ailor, et al.,Curr. Opin. Biotechnol., vol. 10, pp. 142-145 (1999).
Chu, et al.,Gene, vol. 13, pp. 197-202 (1981).
Davis, et al.,Biotechnol. Prog., vol. 16, pp. 736-743 (2000).
Domer, et al.,J. Biol. Chem., vol. 265, pp. 22029-22034 (1990).
Domer, et al.,EMBO J., vol. 11, pp. 1563-1571 (1992).
Graham, et al.,Virology, vol. 52, pp. 456-467 (1973).
Laskowski, et al.,Ann. Rev. Biochem., vol. 49, pp. 593-626 (1980).
Hebert et al.,Cold Spring Harbor Symposia on Quantitative Biology, vol. LX., pp. 405-415 (1995).
Bergeron et al.,TIBS19, pp. 124-128 (Mar. 1994).
Kleizen et al.,Current Opinion in Cell Biology., 16:343-349 (2004).
Conesa, et al.,Applied and Environmental Microbiology, pp. 846-851 (Feb. 2002).
Tate et al.,Journal of Biological Chemistry-, vol. 274, No. 25, pp. 17551-17558 (1999).
Ito et al.,Biochemical and Biophysical Research Communications, 283, 297-302 (2001).
Kaufman et al.,Blood Coagulation and Fibrinolysis, vol. 8, Supp. 2, pp. S3-S14 (1997).
Chan Sham-Yuen
Kelly Ruth
Tang Hsinyi Yvette
Tao Yiwen
Wu Yongjian
Bayer Pharmaceuticals Corporation
Dunston Jennifer
McDonell Boehnen Hulbert & Berghoff LLP
Woitach Joseph
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