Use of molecular chaperones for the enhanced production of...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S352000, C435S358000, C435S366000

Reexamination Certificate

active

07951588

ABSTRACT:
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.

REFERENCES:
patent: 4912040 (1990-03-01), Kaufman et al.
patent: 4965199 (1990-10-01), Capon et al.
patent: 5773245 (1998-06-01), Wittrup et al.
patent: 5914315 (1999-06-01), Sprecher et al.
patent: 6136599 (2000-10-01), Cho
patent: 6333175 (2001-12-01), Glockshuber et al.
patent: 6348192 (2002-02-01), Chan et al.
patent: 6451597 (2002-09-01), Dees et al.
patent: 6476194 (2002-11-01), Tessier et al.
patent: 6583108 (2003-06-01), Tamburini et al.
patent: 2003/0194398 (2003-10-01), Tamburini et al.
patent: 679448 (1994-04-01), None
patent: 2237288 (1991-05-01), None
patent: WO 94/08012 (1994-04-01), None
patent: WO 97/33996 (1997-09-01), None
patent: WO 00/37099 (2000-06-01), None
Hebert et al.,Cold Spring Harbor Symposia on Quantitative Biology, vol. LX., pp. 405-415 (1995).
Bergeron et al.,TIBS19, pp. 124-128 (Mar. 1994).
Kleizen et al.,Current Opinion in Cell Biology., 16:343-349 (2004).
Conesa, et al.,Applied and Environmental Microbiology, pp. 846-851 (Feb. 2002).
Tate et al.,Journal of Biological Chemistry-, vol. 274, No. 25, pp. 17551-17558 (1999).
Ito et al.,Biochemical and Biophysical Research Communications, 283, 297-302 (2001).
Kaufman et al.,Blood Coagulation and Fibrinolysis, vol. 8, Supp. 2, pp. S3-S14 (1997).
Ailor, et al.,Biotechnol. Bioeng., vol. 58, pp. 196-203 (1998).
Dunn, et al.,Biochem. Soc. Trans., vol. 23, p. 78S (1995).
Hsu, et al.,Protein Expr. Purif., vol. 5, pp. 595-603 (1994).
Hsu, et al.,Protein Expr. Purif., vol. 7, pp. 291-288 (1996).
Hsu, et al.,Biotechnol. Prog., vol. 13, pp. 96-104 (1997).
Ostermeier, et al.,J. Biol. Chem., vol. 271, pp. 10616-10622 (1996).
Robinson, et al.,BioTechnology, vol. 12, pp. 381-384 (1994).
Shusta, et al.,Nat. Bio-technol., vol. 16, pp. 773-777 (1998).
Wunderlich, et al.,J. Biol. Chem., vol. 268, pp. 24547-24550 (1993).
Ailor, et al.,Curr. Opin. Biotechnol., vol. 10, pp. 142-145 (1999).
Chu, et al.,Gene, vol. 13, pp. 197-202 (1981).
Davis, et al.,Biotechnol. Prog., vol. 16, pp. 736-743 (2000).
Dorner, et al.,J. Biol. Chem., vol. 265, pp. 22029-22034 (1990).
Dorner, et al.,EMBO J., vol. 11, pp. 1563-1571 (1992).
Graham, et al.,Virology, vol. 52, pp. 456-467 (1973).
Laskowski, et al.,Ann. Rev. Biochem., vol. 49, pp. 593-626 (1980).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of molecular chaperones for the enhanced production of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of molecular chaperones for the enhanced production of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of molecular chaperones for the enhanced production of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2663570

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.