Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-12-03
1999-09-28
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 5, 435 6, 435 72, 435 721, 435 75, 435 21, 435 23, 435 24, 436501, G01N 3353
Patent
active
059587032
ABSTRACT:
The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
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Dower William J.
Heinkel Gregory L.
Mattheakis Larry
Schatz Peter J.
Achutamurthy Ponnathapura
Glaxo Group Limited
Liebeschuetz Joe
Ricigliano Joseph W
Stevens Lauren L.
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