Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-12-07
1990-03-27
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31505
Patent
active
049121111
ABSTRACT:
A method for the promotion or acceleration of wound healing by a treatment with minoxidil is disclosed. The minoxidial can be administered by topical application, oral administration, injection or any combination thereof. Treatment with minoxidil is effective for promoting the migration of epithelial cells in a wound or in tissues such as cornea and the like. Methods for identifying binding sites for minoxidil in cells based on their affinity for the compound in attachment or chemotactic assays are described.
REFERENCES:
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patent: 4596812 (1986-06-01), Chidsey et al.
Murad et al., "Supression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil", J. Biol Chem., vol. 262, No. 25., pp. 11973-11978 (1987).
Schultz, et al., "Epithelial Wound Healing Enhances by Transforming Growth Factor-.alpha. and Vaccinia Growth Factor", Science, vol. 235, pp. 350-352 (1987).
Murad, S., et al., "Selective Depression of Lysyl Hydroxylase Activity in Human Skin Fibroblasts by Minoxidil", J. Invest. Derm., vol. 86, No. 4, p. 496 (Apr. 1986).
Murad, S., et al., "suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil", J. Biol. Chem., vol. 262, No. 25, pp. 11973-11978 (1987).
Pinnell, et al., "Effects of Minoxidil on Cultured Human Skin Fibroblasts", Dermatologica, vol. 175, Suppl. 2, pp. 12-18 (1987).
Ledbetter Steven R.
Martin George R.
Sank Anthony C.
Corneglio Donald L.
Fay Zehyeh A.
NIDR NIH
Robinson Douglas W.
The Upjohn Company
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