Use of microparticles combined with submicron oil-in-water emuls

Details Use of microparticles combined with submicron oil-in-water emuls Use of microparticles combined with submicron oil-in-water emuls

1998-01-29

2000-07-11

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

424 7011, 424 7019, 4242041, 4242281, 4242781, 424280, A61K 3929, A61K 708, A61K 4500, A61K 4744

Patent

active

060869011

ABSTRACT:
Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.

REFERENCES:
patent: 5629167 (1997-05-01), Ratti
patent: 5783567 (1998-07-01), Hedley et al.
patent: 5869103 (1999-02-01), Yeh et al.
Esparza et al. Vaccine, vol. 10 Issues 10 pp. 714-720, Oct 1992.
A.S. Fauci, "Update on the Status of Vaccine Development," Pediatric Aids and HIV Infection: Fetus to Adolescent 5(1):47-58 (1994).
Higgins et al., "MF59 Adjuvant Enhances the Immunogenicity of Influenza Vaccine in Both Young and Old Mice," Vaccine 14(6):478-484 (1996).
Moore et al., "Immunization with a Soluble Recombinant HIV Protein Entrapped in Biodegradable Microparticles Induces HIV-Specific CD8.sup.+ Cytotoxic T Lymphocytes and CD4.sup.+ Th1 Cells," Vaccine 13(18):1741-1749 (1995).
O'Hagan et al., "Biodegradable Microparticles for Oral Immunization," Vaccine 11:149-154 (1993).
O'Hagan, "Recent Advances in Vaccine Adjuvants for Systemic and Mucosal Administration," J. Pharm. Pharmacol 49:1-10 (1997).
Ott et al., "MF59--Design and Evaluation of a Safe and Potent Adjuvant for Human Vaccines," Vaccine Design: The Subunit and Adjuvant Approach (Powell, M.F. and Newman, M.J. eds.) Plenum Press, New York, pp. 277-296 (1995).
Sanchez-Pescador et al., "The Effect of Adjuvants on the Efficacy of a Recombinant Herpes Simplex Virus Glycoprotein Vaccine," The Journal of Immunol. 141(5):1720-1727 (1988).
Vordermeier et al., "Synthetic Delivery System for Tuberculosis Vaccines: Immunological Evaluation of the M. Tuberculosis 38 kDa Protein Entrapped in Biodegradable PLG Microparticles," Vaccine 13(16):1576-1582 (1995).

Affiliated with

Also associated with

Rating

Use of microparticles combined with submicron oil-in-water emuls does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of microparticles combined with submicron oil-in-water emuls, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of microparticles combined with submicron oil-in-water emuls will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-539397