Use of methylnaltrexone and related compounds

Details Use of methylnaltrexone and related compounds Use of methylnaltrexone and related compounds

1997-11-03

1999-10-26

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31485

Patent

active

059729546

ABSTRACT:
A method for preventing or treating opioid induced side effects including dysphoria, pruritus and urinary retention and non-opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered by the route selected from the group consisting of intravenous, intramuscular, transmucosal, transdermal, and oral administration, preferably administered orally in an enterically coated form.

REFERENCES:
patent: 4176186 (1979-11-01), Goldberg et al.
Yuan et al., Clin. Pharmacol. Ther., 59(4), 469-475 (abstract), 1996.
Yuan, Chun Su et al., European Journal of Pharmacology, 276:107-111, 1995.
Yuan, Chun Su et al., Clinical Pharmacology & Therapeutics, 61:467-75, 1997.
Foss, Joseph F., The Journal of Clinical Pharmacology, 1997;37:25-30.
Yuan, Chun Su et al., Clinical Pharmacology & Therapeutics, 59:469-75, 1996 .

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