Use of methyl donor compounds to treat neurological dysfunction

Details Use of methyl donor compounds to treat neurological dysfunction Use of methyl donor compounds to treat neurological dysfunction

1996-03-29

1998-02-10

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514903, A61K 3168, A61K 3170, A61K 19052

Patent

active

057169411

ABSTRACT:
A method for treating a mammal with a demyelinating disease associated with an immunological disorder comprising administering methylcobalamin or cyanocobalamin.

REFERENCES:
patent: 5508271 (1996-04-01), Rabinoff
Kieburtz et al., "Abnormal Vitamin B.sub.12 Metabolism in Human Immunodeficiency Virus Infection," Arch. Neurol. (1991), 48:312-314.
Pfohl et al., "Effect of Cobalamin Derivatives on In Vitro Enzymatic DNA Methylation: Methycobalamin Can Act as a Methyl Donor," Biochemistry (1991), 30:8045-8051.
Sakane et al., "Effects of Methyl-B.sub.12 on the In Vitro Immune Functions of Human T Lymphocytes," J. of Clin. Immunology (1982), 2:101-109.
Scott and weir, "Hypothesis: The Methyl Folate Trap," The Lancent (1981), 337-340.
Surtees et al., "Association of Demyelination with Deficiency of Cerebrospinal-fluid S-adenosylmethionine in Inborn Erros of Methly-transfer Pathway," The Lancet (1991), 338:1550-1554.
Surtees et al., "Central-nervous-system Methyl-group Metabolism in Children with Neurological Complications of HIV Infection," The Lancet (1990), 335:619-621.
Yaqub et al., "Effects of methylcobalamin on Diabetic Neuropathy," Clinical Neurology and Neurosurgery (1992), 94:105-111.
Whitaker and Mitchell, "A Possible Role for Altered Myelin Basic Protein in Multiple Sclerosis," Annals of Neurology (1996), 40:3-4.
Kira et al., "Vitamin B.sub.12 Metabolism and Massive-Dose Methyl Vitamin B.sub.12 Therapy in Japanese Patients with Multiple Sclerosis," Internal Medicine (1994), 33:82-86.
Glass et al., "Hydroxocobalamin. I. Blood Levels and Urinary Excretion of Vitamin B.sub.12 in Main After a Single Parenteral Dose of Aqueous Hydroxocobalamin, Aqueous Cyanocabalamin and Cyanocobalamin Zinc-Tannate Complex," Blood (1961), 18:511-521.
Beck, "Cobalamin and The Nervous System," The New England J. of Medicine (1988), 318:1752-1754.
Simpson and Miller, "The Treatment of Multiple Sclerosis with Massive Doses of Hydroxocobalamin," Neurology, 15:599-603, 1992.

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